Torii and Hashimoto-Torii labs at Children’s National Health System in Washington, DC have two opening postdoc positions supported by NIH funding.
One of the positions seeks a person who has a strong background in molecular biology, biochemistry or systems biology (bioinformatics). The other position is available for a person who has experience in in vivo imaging or electrophysiology. Each will have a primary position in either of the two labs. However, they are expected to join the collaborative projects between the labs.
Research in the Torii lab focuses on deciphering the complex mechanisms of cell positioning and neural circuit formation in the developing cerebral cortex, and translating the findings into the development of novel therapeutic approaches for neurodevelopmental disorders such as schizophrenia and autism. Toward this goal, the lab uses various tools and techniques, including in vivo gene manipulation, induced pluripotent stem (iPS) cells, transgenic animals and animal disease models, proteomic and transcriptomic analyses, and cell transplantation.
The Hashimoto-Torii lab seeks to understand how an adverse prenatal environment interacts with genetic predisposition, thereby increasing disease susceptibility after birth. Harmful conditions, such as hypoxia, exposure to excessive levels of heavy metals, and maternal smoking and alcohol intake are thought to reprogram normal fetal brain development and consequently increase the incidence of many childhood disorders, including lower birth weight, SIDS, pediatric epilepsy, schizophrenia and ADHD. However, the mechanisms underlying such reprogramming remain unknown. With a focus on the cerebral cortex, the team tackles this question through a combination of wet and dry analyses using mouse and human research models. The lab is also testing novel drugs and devices to improve behavioral problems in the offspring after in utero exposure to harmful agents.
If interested, please send a statement of your research interests and career goals, along with your CV and contact information of two references to firstname.lastname@example.org and email@example.com.
Torii, M., Sasaki, M., Son, A., Mohammad, S., Chang, Y., Waxman, G.S., Kocsis, D. J., Rakic, P. and Hashimoto-Torii, K. Early detection of cellular damage by environmental and physical insults in mice. Proc Natl Acad Sci U S A, 2017 AOP
Ishii, S., Torii, M., Son, A.I., Rajendraprasad, M., Morozov, M.Y., Imamura Kawasawa Y., Salzberg, A.C., Fujimoto, M., Brennand K., Nakai, A., Mezger, V., Gage, F., Rakic, P. and Hashimoto-Torii, K., Variations in brain defects result from cellular mosaicism in response to prenatal stress Nat. Commun, 2017 In Press
Son, A.I., Fu, X., Suto, F., Liu J.S., Hashimoto-Torii, K., Torii, M. Proteome dynamics during postnatal mouse corpus callosum development. Sci Rep, 2017 In Press
Masaaki Torii, Ph.D.
Kazue Hashimoto-Torii, Ph.D.
Principal Investigators, Center for Neuroscience Research
Children’s Research Institute, Children’s National Health System
Assistant Professors, Department of Pediatrics, Pharmacology and Physiology
The George Washington University School of Medicine and Health Sciences
111 Michigan Avenue, N.W.,
Washington DC, 20010-2970
Ph: 202-476-4279 (Torii), 4449 (Hashimoto-Torii)