Our division has analyzed molecular profiles of human primary medulloblastoma, one of the most common malignant brain tumors in children using the next generation sequencing technologies (whole genome sequencing, ChIP-seq, methylome sequencing, etc.). Based on these accumulated bioinformative data, my research group is currently investigating molecular mechanisms underlying formation of medulloblastoma using mouse models. Fascinating questions in medulloblastoma biology are what cells are their cellular origin(s), what oncogenic impact(s) drive their tumor formation and how normal cells transform into malignant tumor cells. To answer these questions, we will take advantage of germline and non-germline genetically engineered mouse models with the Cre-LoxP technology, molecular biology (e.g. the CRISPR/Cas9 technology), animal imaging, next generation sequencing technologies (e.g. single cell RNA-seq) as well as iPSC-based humanized models. This position is supported by the third party funding for maximum 4 years. Further information is on our lab website:
Applicants must have (within 5 years) or to be expected to receive a PhD with a track record of publications in peer-reviewed journals. We would be glad to receive applications from highly motivated scientists with a strong expertise in developmental biology, neuroscience and mouse genetics. The scientist on this position is expected to work independently but collaboratively with internal and external scientists. Excellent English communication skill for scientific discussion is required.
Heidelberg is very famous academic city in Germany. It has EMBL, Heidelberg university, Max-Plank and German Cancer Research Center (DKFZ). For this reason, the city is very peaceful and English is acceptable in many places of the city. DKFZ is one of the biggest cancer research centers in Europe. For postdocs, DKFZ offers not only great environment for research (with many international conferences), but also carrier development courses (e.g. grant/manuscript writing training, lab management, etc.) with no charges, which would be helpful for young researchers to become a independent scientist. Within the institute, all scientific discussion is done in English.
Start of Employment
As early as possible, but negotiable in 2017.
Required Documents for Application
-Complete CV including a publication list, experimental skills as well as contact information of at least three references
-Description of current and previous research summary
-A letter for motivation for this position
*Please feel free to contact me, if any questions/interest regarding this position.
Daisuke Kawauchi, PhD.
Group head of “Developmental Neuro-Oncology”
German Cancer Research Center (DKFZ.)
Foundation under Public Law
Im Neuenheimer Feld 580