iPS cells are pluripotent cells which give rise to all cells in the organism. It is well-known that dopamine is a key modulator in the brain control, motor function, emotional states and endocrine physiology. Furthermore, it has been reported that dopamine receptor agonists regulate cell cycle and proliferation. In the present study, we evaluated the change in the dopaminergic system of familial Parkinson's disease- specific "induced pluripotent stem cell" (iPSCs)-derived neurons. Here we profiled the expression of dopamine-related genes in undifferentiated human iPS cells and differentiated neural stem cells. Dopamine D1 and D2 receptors were expressed along with the progress of cell differentiation. Interestingly, D3 receptor expression was gradually decreased with the progress of cell differentiation. Furthermore, we generated the Parkinson disease-specific iPSCs and investigated the possible change in dopamine receptor expression. Expression of dopamine D1 receptor was dramatically decreased in Parkinson's disease specific-iPSCs-derived dopaminergic neurons, whereas dopamine D2 receptor was significantly increased in Parkinson's disease specific-iPSCs-derived dopaminergic neurons. Under these conditions, there were no differences in the potency of differentiation into dopaminergic neurons between control and Parkinson's disease. These findings suggest that the changes in the expression of dopamine receptors in Parkinson's disease specific-iPSCs-derived dopaminergic-neurons could affect neural dysfunction and degeneration.