Changes in excitatory and inhibitory synaptic inputs after the peripheral nerve injury are an initial step for reorganizing neural circuit and topographical map in the somatosensory system (Chen et al., Neuroscience, 2002). In the ventral posterior medial nucleus (VPM) of the somatosensory thalamus, the majority of VPM relay neurons are usually innervated by a single strong medial lemniscal fiber with GluA2 negative AMPA receptors after developmental synapse elimination. We previously reported that the infraorbital nerve cut (IONC) operation recruits additional medial lemniscal fibers with GluA2 positive AMPA receptors onto VPM relay neurons around 5 days after the operation (POD5) (Takeuchi et al., J Neurosci., 2012). However, little is known about the detail of the postoperative change in inhibitory GABA currents onto VPM relay neurons after the IONC. Here we report that the increase in tonic GABA currents after the IONC (from POD1-3) occurred much earlier than the remodeling of lemniscal fibers onto VPM relay neurons. Interestingly, potentiated tonic GABA current after the IONC was selectively observed in VPM relay neurons, which had multiple lemniscal fibers by the IONC, at POD7-9. Moreover, chronic treatment of extrasynaptic GABA_A receptor agonist into the VPM of normal mice recruited newly lemniscal fibers with GluA2 positive AMPA receptors at postsynaptic sites. These results provide the possibility that enhancement of tonic GABA inhibition by the IONC drives the remodeling of lemniscal fibers with GluA2-positive AMPA receptors on a VPM neuron.