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開催日 2014/9/13
時間 11:00 - 12:00
会場 Poster / Exhibition(Event Hall B)

In vivo Magnetic Resonance Imaging at 11.7 Tesla Visualized the Effects of Neonatal Transection of Infraorbital Nerve upon Primary and Secondary Trigeminal Pathways in Rats

  • P3-341
  • 大井 康浩 / Yasuhiro Ooi:1,2 乾(山本) 千珠子 / Chizuko Inui-Yamamoto:3 豊田 浩士 / Hiroshi Toyoda:2 精山 明敏 / Akitoshi Seiyama:4 吉岡 芳親 / Yoshichika Yoshioka:2,5 関 淳二 / Junji Seki:6 
  • 1:大阪大学歯学研究科歯科薬物学講座 / Division of Pathogenesis and Control of Oral Disease, Graduate School of Dentistry, Osaka University, Osaka, Japan 2:情報通信研究機構・大阪大学 脳情報通信融合研究センター / Center for Information and Neural Networks (CiNet), National Institute of Information and Communication Technology (NICT) and Osaka University, Osaka, Japan 3:大阪歯科大学 口腔解剖学講座 / Department of Oral Anatomy, Osaka Dental University, Osaka, Japan 4:京都大学大学院医学研究科人間健康科学系専攻医療診断機器学分野 / Division of Medical Devices for Diagnoses, Faculty of Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan 5:大阪大学免疫学フロンティア研究センター 生体機能イメージング講座 / Biofunctional Imaging Laboratory, Immunology Frontier Research Center, Osaka University, Osaka, Japan 6:関西大学先端科学技術推進機構 / Organization for Research and Development of Innovative Science and Technology, Kansai University, Osaka, Jap 

Using 11.7 T ultra high-field T2-weighted MRI, the present study aimed to investigate pathological changes of primary and secondary trigeminal pathways following neonatal transection of infraorbital nerve in rats. The trigeminal pathways consist of spinal trigeminal tract, trigeminal sensory nuclear complex, medial lemniscus, ventromedial portion of external medullary lamina and ventral posterior nucleus of thalamus. By selecting optimum parameters of MRI such as repetition time, echo time, and slice orientation, this study visualized the trigeminal pathways in rats without any contrast agents. Pathological changes due to the nerve transection were found at 8 weeks of age as a marked reduction of the areas of the trigeminal pathways connecting from the injured nerve. In addition, T2-weighted MR images of the trigeminal nerve trunk and the spinal trigeminal tract suggest a communication of CSF through the trigeminal nerve between inside and outside of the brain stem. These results support the utility of ultra high-field MRI system for noninvasive assessment of effects of trigeminal nerve injury upon the trigeminal pathways.

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