• Top page
  • Timetable
  • Per session
  • Per presentation
  • How to
  • Meeting Planner



Olfactory and Auditory system

開催日 2014/9/13
時間 9:00 - 10:00
会場 Room J(313+314)
Chairperson(s) 山口 正洋 / Masahiro Yamaguchi (東京大学大学院医学系研究科 細胞分子生理学教室 / Department of Physiology, Graduate School of Medicine, the University of Tokyo, Japan)
風間 北斗 / Hokuto Kazama (独立行政法人 理化学研究所 脳科学総合研究センター 知覚神経回路機構研究チーム / Laboratory for Circuit Mechanisms of Sensory Perception Brain Science Institute, RIKEN, Japan)

Motivational state-dependent activation of distinct subregions of the mouse olfactory tubercle

  • O3-J-1-3
  • 村田 航志 / Koshi Murata:1,2 菅野 未知子 / Michiko Kanno:1,2 家城 直 / Nao Ieki:1,2 森 憲作 / Kensaku Mori:1,2 山口 正洋 / Masahiro Yamaguchi:1,2 
  • 1:東京大院医細胞分子生理 / Dept Physiol, Univ of Tokyo, Tokyo, Japan 2:JST-CREST / JST-CREST, Tokyo, Japan 

Olfaction plays a key role in inducing motivation behaviors such as approaching to and eating food and being vigilant against and avoiding potential dangers. However, it is unclear how central olfactory circuits initiate odor-induced motivation behaviors. The olfactory tubercle (OT) is part of the ventral striatum and receives olfactory sensory information via the olfactory bulb and olfactory cortex. The OT sends GABAergic outputs onto the ventral pallidum and disinhibits the thalamus, hypothalamus and ventral tegmental area, which may trigger motivation behaviors. To test the idea that the OT functions as a switchboard for odor-induced motivation behaviors, we trained different groups of mice to associate a same odor cue with either attractive sugar reward or aversive electrical shock punishment, and histologically compared distribution of c-Fos mRNA expressing-cells in the OT among mice that showed different behavioral responses to the conditioned odor cue. In mice that showed approaching response to the sugar-associated odor, a large number of c-Fos(+) cells were observed in rostro-medial portion of the cortex-like region of the OT. On the other hand, in mice that showed vigilant response to the shock-associated odor, a large number of c-Fos(+) cells were observed in the cap region, medial portion of the islands of Calleja, and lateral portion of the cortex-like region of the OT. The results suggest that specific subregions of the OT are involved in distinct odor-induced motivation behaviors.

Copyright © Neuroscience2014. All Right Reserved.