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演題詳細

Poster

自律神経系
Autonomic Nervous System

開催日 2014/9/11
時間 16:00 - 17:00
会場 Poster / Exhibition(Event Hall B)

ボンベシン脳室内投与はラット視床下部室傍核前交感神経性ヘモグロビン含有ニューロンを活性化する
Centrally administered bombesin activates hemoglobin-containing pre-sympathetic neurons in rat hypothalamic paraventricular nucleus

  • P1-194
  • 田中 健二朗 / Kenjiro Tanaka:1 清水 孝洋 / Takahiro Shimizu:2 齊藤 源顕 / Motoaki Saito:2 由利 和也 / Kazunari Yuri:1 
  • 1:高知大・医・解剖 / Dept Neurobiol Anat, Kochi Med Sch, Kochi Univ, Japan 2:高知大・医・薬理 / Dept Pharmacol, Kochi Med Sch, Kochi Univ, Japan 

A hemoglobin α-chain-derived peptide RVD-hemopressin is reported as a ligand for cannabinoid CB1 receptors. We previously showed that RVD-hemopressin inhibited centrally administered bombesin (a stress-related peptide)-induced secretion of adrenal catecholamines (adrenaline and noradrenaline) in the rat, suggesting an inhibitory role of brain cannabinoid system in the sympatho-adrenomedullary outflow. In this study, pre-sympathetic spinally projecting neurons of the rat hypothalamic paraventricular nucleus (PVN), which are thought to regulate the adrenal response, were labeled with a fluorescent retrograde tracer. Then, we examined the immunoreactivity of hemoglobin α-chain or RVD-hemopressin with neuronal activation marker Fos in the fluorescently labeled pre-sympathetic neurons following the intracerebroventricular administration of bombesin. The bombesin induced Fos immunoreactivity in pre-sympathetic PVN neurons with hemoglobin α-chain immunoreactivity. RVD-hemopressin-like immunoreactivity was also detected in pre-sympathetic neurons of the PVN. These findings implicate the involvement of hemoglobin α-chain and RVD-hemopressin in modulating sympatho-adrenomedullary outflow.

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