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Synaptic Plasticity

開催日 2014/9/11
時間 16:00 - 17:00
会場 Poster / Exhibition(Event Hall B)

Nogo restricts adult neural plasticity by limiting synaptic AMPA receptors delivery

  • P1-058
  • 実木 亨 / Susumu Jitsuki:1 中島 和希 / Waki Nakajima:1 高橋 琢哉 / Takuya Takahashi:1,2 
  • 1:横浜市立大学大学院 医学研究科 生理学 / Department of Physiology, Yokohama City University Graduate School of Medicine, Yokohama, Japan 2:アルバートアインシュタイン医科大学 / Department of Neuroscience, Albert Einstein College of Medicine, New York, USA 

While experience early in life actively refines neural circuits by virtue of a high capacity for plasticity, experience-dependent plasticity and improvement of function is prominently limited in adult brain. However, the molecular and cellular mechanisms underlying how experience-driven neural plasticity is restricted in adult brain remain poorly understood. Removal of the myelin-inhibiting signaling protein, Nogo receptor (NgR1), restores adult neural plasticity. Here we found that, in NgR1-deficient mice, whisker experience-driven synaptic AMPA receptor (AMPAR) insertion in the barrel cortex, normally complete by 2 weeks after birth, lasts into adulthood, leading to a sharpened whisker-barrel map. In vivo live imaging by two-photon microscope revealed more AMPAR on the surface of spines in the adult barrel cortex of NgR1-deficient than wild-type mice. Further, we found that whisker stimulation produced new spines in the adult barrel cortex of mutant but not of wild-type mice, and the newly synthesized spines contained more surface AMPAR than did the existing spines in mutant mice. These results suggest that Nogo signaling limits plasticity by restricting synaptic AMPAR delivery in coordination with anatomical plasticity.

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