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Memory and Temporal Cognition

開催日 2014/9/13
時間 10:00 - 11:00
会場 Room H(304)
Chairperson(s) 定藤 規弘 / Norihiro Sadato (自然科学研究機構 生理学研究所 大脳皮質機能研究系 / Department of Cerebral Research, National Institute for Physiological Sciences, Japan)
北澤 茂 / Shigeru Kitazawa (大阪大学大学院生命機能研究科 / Osaka University, Graduate School of Frontier Biosciences, Japan)

Dissociable activity patterns in the macaque medial temporal lobe during memory encoding predict subsequent recognition performance

  • O3-H-2-2
  • 宮本 健太郎 / Kentaro Miyamoto:1 足立 雄哉 / Yusuke Adachi:1 長田 貴宏 / Takahiro Osada:1 渡部 喬光 / Takamitsu Watanabe:1 木村 紘子 / Hiroko M Kimura:1 節家 理恵子 / Rieko Setsuie:1 渡辺 朋美 / Tomomi Watanabe:1 宮下 保司 / Yasushi Miyashita:1 
  • 1:東京大学大学院 / The Univ.of Tokyo, Japan 

Functional magnetic resonance imaging (fMRI) studies have revealed that activity in the medial temporal lobe (MTL) predicts subsequent memory performance in humans. Because of limited knowledge on cytoarchitecture and axonal projections of the human MTL, precise localization and characterization of the areas that can predict subsequent memory performance are benefited by the use of nonhuman primates in which integrated approach of the MRI- and cytoarchiture-based boundary delineation is available. However, neural correlates of this subsequent memory effect have not yet been identified in monkeys. To identify memory traces in the macaque MTL, we conducted fMRI experiments of two macaque monkeys performing a serial probe recognition task in a 4.7T MRI scanner. In this task, monkeys viewed a list of serially presented picture items and, after a delay, judged whether the test item was seen or unseen in the list. Here, we focused on the memory encoding activity of events that monkeys later remembered or forgot. Application of both multivoxel pattern analysis and conventional univariate analysis to high-resolution fMRI data allowed us to identify memory traces within the caudal entorhinal cortex (cERC) and perirhinal cortex (PRC), as well as within the hippocampus proper. Furthermore, activity in the cERC and the hippocampus, which are directly connected, was responsible for encoding the initial items of sequentially presented pictures related to the primacy effect in the task, which may reflect recollection-like recognition, whereas activity in the PRC was not. These results suggest that two qualitatively distinct encoding processes work in the monkey MTL and that recollection-based memory is formed by the interplay of the hippocampus with the cERC, a focal cortical area anatomically closer to the hippocampus and hierarchically higher than previously believed. These findings will advance the understanding of common memory system between humans and monkeys.

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