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Axonal Regeneration and Tissue Repair

開催日 2014/9/13
時間 11:00 - 12:00
会場 Poster / Exhibition(Event Hall B)

LOTUS suppresses chondroitin sulfate proteoglycans-induced axonal growth inhibition

  • P3-079
  • 栗原 裕司 / Yuji Kurihara:1 齋藤 優 / Yu Saito:1 竹居 光太郎 / Kohtaro Takei:1 
  • 1:横浜市大院・生命医・生体機能医 / Mol. Med. Biosci. Lab., Grad. Sch. of Med. Life Sci., Yokohama City Univ., Yokohama, Japan 

Axon growth inhibitors such as Nogo proteins, myelin-associated glycoprotein (MAG), oligodendrocyte myelin glycoprotein (OMgp), and B lymphocyte stimulator (BLyS) commonly bind to Nogo receptor-1 (NgR1), leading to enormous restriction of functional recovery after damage to the adult central nervous system (CNS). Previous study shows that chondroitin sulfate proteoglycans (CSPGs) are also identified as the functional ligands for NgR1 and that the binding of CSPGs to NgR1 limits neuronal regeneration after CNS damage. We identified lateral olfactory tract usher substance (LOTUS) as a novel molecule that functions in axonal bundle formation by antagonizing Nogo-induced NgR1 function. Recently, we found that LOTUS antagonizes NgR1 when bound by MAG, OMgp, and BLyS. However, whether LOTUS exerts antagonism of NgR1 when bound by CSPGs has not been determined. In cultured dorsal root ganglion neurons in which endogenous LOTUS is only weakly expressed, overexpression of LOTUS suppressed CSPGs-induced growth cone collapse. Our data suggest that LOTUS functions as an endogenous potent antagonist for NgR1 when bound by all five ligands for NgR1, raising the possibility that LOTUS may protect neurons from NgR1-mediated axonal growth inhibition and thereby may be useful for promoting neuronal regeneration as a potent inhibitor of NgR1.

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