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RNA の制御と機能、翻訳制御
Regulation and Function of RNA, Translational Regulation

開催日 2014/9/13
時間 11:00 - 12:00
会場 Poster / Exhibition(Event Hall B)

Glial miR expression following basic fibroblast growth factor application in astrocytes

  • P3-043
  • 山本 宜子 / Noriko Yamamoto:1 沼川 忠弘 / Tadahiro Numakawa:1 中島 進吾 / Shingo Nakajima:1 大島 淑子 / Yoshiko Ooshima:1 小高 陽樹 / Haruki Odaka:1 橋戸 和夫 / Kazuo Hashido:2 安達 直樹 / Naoki Adachi:1 功刀 浩 / Hiroshi Kunugi:1 
  • 1:国立精神・神経セ神経研疾病3 / Dept. of Mental Disorder Research, Nat'l Inst. of Neurosci., NCNP, Tokyo, Japan 2:国立精神・神経セ神経研RI管理室 / Administrative Section of Radiation Protection, NCNP, Tokyo, Japan 

Gene expression is also regulated by microRNAs (miRs), which play a role in regulating
expression levels of mRNAs targeted. Recently, it has been suggested that dynamic of specific miRs participate in the development of diseases and is useful for diagnosis of diseases.
Previously, we demonstrated that brain-derived neurotrophic factor (BDNF) increased
miR-132 and the increased miR-132 has a positive effect on upregulation of synaptic proteins in cortical neuronal cells (Numakawa et al 2011.Neurochem Int.), although function of glial miRs are not well-studied. Here, we examined effect of basic fibroblast growth factor (bFGF), which is one of the growth factors, on expression of glial miRs using pure astroglial cultures. We observed that miRNA-134 was increased after bFGF application although other growth factors including BDNF and glial cell line-derived neurotrophic factor were not effective, implying that bFGF/miR systecontributes to glial function. This study was supported by grants from the Grant-in-Aid for Challenging Exploratory Research (JSPS KAKENHI Grant Number 25640019) (T. N.) and for Scientific Research (B) (JSPS KAKENHI 24300139) (T. N.) in the Ministry of Education, Culture, Sports, Science, and Technology of Japan.

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