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Axonal/Dendritic Growth and Circuit Formation

開催日 2014/9/13
時間 11:00 - 12:00
会場 Poster / Exhibition(Event Hall B)

Coactosin, an actin-remodeling protein, activates critical period plasticity

  • P3-059
  • 侯 旭濱 / Xubin Hou:1 﨑村 建司 / Kenji Sakimura:2 杉山 清佳 / Sayaka Sugiyama:1 
  • 1:新潟大院・医歯学・神経発達 / Lab. of Neuronal Development, Dept Med, Niigata Univ. Niigata, Japan 2:新潟大・脳研・細胞神経生物学 / Dept Cellular Neurobiology, Brain Research Inst, Niigata Univ. Niigata, Japan 

Binocular vision is established in the primary visual cortex (V1) through activity-dependent competition during early postnatal life. Neuronal circuit rewiring reflects a well-orchestrated balance of excitation and inhibition. Our previous report showed that transfer of Otx2 homeoprotein into parvalbumin (PV)-cells regulates the critical period plasticity. Genetic cascade induced by Otx2 may underlie maturation of PV-cell circuits and perineuronal net enrichment. Here, we show that Coactosin is specifically localized in PV-cells at a peak of critical period (P28) then enhanced by adulthood (>P60). The distribution attenuates in Otx2 depletion or dark raring, suggesting that Coactosin serves as a downstream effector of Otx2. In Coactosin heterozygous null mice, visual evoked potentials (VEPs) from the binocular zone revealed that the onset of ocular dominance plasticity was impaired even at the critical period ages after a brief monocular deprivation (4 days), although the mutant mice exhibit a normal development of visual acuity. Thus, Coactosin may serve as a novel potential regulator of cortical plasticity. Importantly, Coactosin played a role for the formation of neuronal processes through facilitating actin polymerization (Hou et al., 2013). Localization of Coactosin mRNA in neuronal processes suggested local translation of this molecule. It would be interested to analyze whether Otx2 homeoprotein regulates translation of this actin-remodeling factor.

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