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Spatial and Temporal Cognition

開催日 2014/9/11
時間 16:00 - 17:00
会場 Poster / Exhibition(Event Hall B)

Hippocampal-habenular interaction in the freely behaving mouse

  • P1-252
  • Thomas J. Mchugh:1 Roman Boehringe:1 Denis Polygalov:1 Hitoshi Okamoto:1 
  • 1:RIKEN Brain Science Institute 

The rodent hippocampus is crucial for contextual and spatial learning and its principle neurons display place specific firing that underlies this role (hippocampal 'place cells'). Little is known, however, about how salient events, be they positive (reward) or negative (punishment), modulate the hippocampal spatial map. The lateral habenula (LHb) has attracted growing interest as a regulator of monoaminergic neurons in the central nervous system. It remains unclear however, how the LHb modulates brain states and influences memory. Recent evidence has demonstrated that the lateral habenula, a region known to encode negative outcomes in the primate brain, can directly impact hippocampal oscillations in the behaving rat (Aizawa et al., 2013). Further, data also suggests this relationship is bidirectional and LHb neurons themselves can organize their spiking relative to the oscillations in the hippocampus. To better understand the interactions between these structures and how the place-salience relationship may be encoded and consolidated we conducted in vivo recordings simultaneously in the lateral habenula and dorsal region CA1 of the hippocampus in mice receiving spatially cued aversive stimuli. Our results suggest that interactions occurring between these regions, both during behavior and after, may play an important role in establishing memories that carry both spatial and reward/punishment information.

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