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Drug Addiction and Abuse

開催日 2014/9/12
時間 14:00 - 15:00
会場 Poster / Exhibition(Event Hall B)

The involvement of chronic social deprivation on alcohol consumption in μ-opioid receptor knockout mice

  • P2-348
  • 森屋 由紀 / Yuki Moriya:1,2 笠原 好之 / Yoshiyuki Kasahara:1,2 Hall F. Scott / F. Scott Hall:3 Uhl George R. / George R. Uhl:3 富田 博秋 / Hiroaki Tomita:1,2 曽良 一郎 / Ichiro Sora:1,4 
  • 1:東北大学大学院医学系研究科 精神神経生物学分野 / Dept. of Biological Psychiatry, Tohoku Univ. Graduate School of Medicine 2:東北大学大学院医学系研究科 災害精神医学分野 / Dept. of Disaster Psychiatry, Tohoku Univ. Graduate School of Medicine 3:Molecular Neurobiology Branch, Intramural Research Program, National Institute on Drug Abuse, MD, USA / Molecular Neurobiology Branch, Intramural Research Program, National Institute on Drug Abuse, MD,USA 4:神戸大学大学院医学研究科 精神医学分野 / Dept. of Psychiatry, Kobe Univ. Graduate School of Medicine, Japan 

Rationale:Although evidence based on clinical and experimental animal studies consistently indicates that social isolation stress influences alcohol consumption, probably by influencing stress response systems, the mechanisms underlying the interaction between the phenomena remain unelucidated. Since μ-opioid (MOP) signaling has been reported to have key roles in both stress responses and reward/addictive behaviors, MOP can be a candidate molecule to link between social isolation stress and alterations in drinking behavior.
Objectives:To characterize alcohol consumption of MOP KO and wild type (WT) mice exposed to social isolation stress and evaluate the effects of MOP signaling into the link between the stress and alcohol consumption.
Methods:Mice were randomly assigned to eight groups; socially-reared WT male (n=15), socially-reared WT female (n=15), isolation-reared WT male (n=14), isolation-reared WT female (n=11), socially-reared MOP KO male (n=14), socially-reared MOP KO female (n=8), isolation-reared MOP KO male (n=10), and isolation-reared MOP KO female (n=10), and alcohol consumption behavior was evaluated for each group using a two-bottle home-cage consumption (ethanol 8% vs. water) paradigm.
Results:Isolation rearing had no effects upon alcohol consumption in WT mice; however, isolation rearing significantly altered amount of alcohol consumption in both male and female MOP KO mice. Interestingly, these effects were in the opposite direction, increasing alcohol consumption in male mice, but decreasing alcohol consumption in female mice.
Conclusion:These results suggest that MOP influences alcohol consumption in species exposed to social isolation stress, and also MOP signaling may cause alterations oppositely in drinking behaviors of male and female mice.

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