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Somatosensory System

開催日 2014/9/12
時間 14:00 - 15:00
会場 Poster / Exhibition(Event Hall B)

The top-down circuit for sensory perception in the cerebral cortex of the mouse

  • P2-176
  • 真仁田 聡 / Satoshi Manita:1 鈴木 崇之 / Takayuki Suzuki:1 本間 千尋 / Chihiro Homma:1 松元 崇 / Takashi Matsumoto:1 小田川 摩耶 / Maya Odagawa:1 山田 一之 / Kazuyuki Yamada:1 太田 桂輔 / Keisuke Ota:1,7 松原 智恵 / Chie Matsubara:1 犬束  歩 / Ayumu Inutsuka:2 佐藤 正晃 / Masaaki Sato:1,3 大倉 正道 / Masamichi Ohkura:4 山中 章弘 / Akihiro Yamanaka:2 柳川 右千夫 / Yuchio Yanagawa:5 中井 淳一 / Junichi Nakai:1,4 林 康紀 / Yasunori Hayashi:1,4 Larkum Mat / Matthew E Larkum:6 村山 正宜 / Masanori Murayama:1 
  • 1:独立行政法人理化学研究所 / RIKEN BSI 2:名大・環境医学研究所 神経系分野Ⅱ / Dept. of Neuroscience II, Research Institute of Environmental Medicine, Nagoya University, Aichi, Japan 3:JSTさきがけ / JST, PRESTO, Saitama, Japan 4:埼玉大・脳末梢科学研究センター / Brain Science Institute, Saitama University, Saitama, Japan 5:群馬大・大学院医学系研究科・遺伝発達行動学分野 / Dept. of Genetic and Behavioral Neuroscience, Gunma University Graduate School of Medicine, Gunma, Japan 6:Neurocure Cluster of Excellence, Humboldt University, Berlin, Germany / Neurocure Cluster of Excellence, Humboldt University, Berlin, Germany 7:日本学術振興会特別研究員PD / JSPS Research Fellow 

Top-down information flow is as much a fundamental part of the process of accurate perception as is bottom-up flow. Despite its importance for perception, little is known about the mechanisms of top-down control. We report the identification and characterization of a neural circuit controlled by top-down input in the mouse somatosensory system. The circuit consists of a long-range recurrent horizontal projection between the S1 primary somatosensory cortex and the M2 secondary motor cortex. Physiological recordings revealed that M2 top-down input provides temporally coincident input to the upper and lower layers of the S1, initiating dendritic spikes and selective firing of layer 5 (L5) neurons. Optogenetic inhibition of top-down feedback input in the S1 reduced L5 firing, causing an inaccurate perception of tactile information. These data showed that top-down inputs from M2 to S1 play an important role in accurate sensory perception, which is realized by dendritic and somatic spikes in L5 pyramidal neurons.

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