演題詳細
Oral
ヒト高次脳機能
Human Higher Brain Functions
| 開催日 | 2014/9/13 |
|---|---|
| 時間 | 15:00 - 16:00 |
| 会場 | Room H（304） |
| Chairperson(s) | 有光 威志 / Takeshi Arimitsu (慶應義塾大学医学部小児科学教室 / Department of Pediatrics, School of Medicine, Keio University, Japan) 小西 清貴 / Seiki Konishi (順天堂大学 医学部 生理学講座 / Department of Physiology, Juntendo University School of Medecine, Japan) |
言語発達の予期因子としての音韻に対する新生児脳反応
Neonatal cerebral responses to linguistic phonetic differences predict later language development
- O3-H-3-1
- 河合（皆川） 泰代 / Yasuyo Minagawa:1 有光 威志 / Takeshi Arimitsu:2 松崎 敦子 / Atsuko Matsuzaki:3 柳橋 達彦 / Tatsuhiko Yagihashi:2,4 山本 淳一 / Jun-ichi Yamamoto:3 池田 一成 / Kazushige Ikeda:2 高橋 孝雄 / Takao Takahashi:2
- 1:慶應大・文・心理 / Dept Psychol, Keio Univ, Tokyo, Japan 2:慶應大医小児科 / Dept Pediatr, Keio Univ, Sch of Med, Tokyo, Japan 3:慶應大院社研 / Grad Sch of Human Relations, Keio Univ, Tokyo, Japan 4:駒木野病院児童精神科 / Dept Child Psychiatry, Komagino Hospital, Tokyo, Japan
Language delay is one of the major cognitive problems that preterm infants may experience. While early detection and intervention is crucial, there is little data on how such developmental impairments may be detected with reliable behavioral and neuronal markers. To understand the relationship between early neurocognitive traits and developmental outcomes, we are currently performing a longitudinal prospective cohort study, examining behavior and brain function from birth to 3 years of age. This is a preliminary report from this cohort. We examined whether cerebral responses to linguistic contrasts are related to development of motor and cognitive skills, and language abilities. Longitudinal data obtained from 14 term infants and 13 preterm infants were used in this analysis. Cerebral responses to phonemic and prosodic contrasts were measured using NIRS at 33 to 40 weeks (corrected gestational age). We analyzed the hemodynamic response function (HRF) for multiple channels and laterality indices of the auditory area. In a follow-up test, we assessed infants' general development using the Kyoto Scale of Psychological Development (KSPD) and MacArthur-Bates Communicative Developmental Inventories (CDI). Results of correlation analyses revealed significant correlations between the HRF typicality score for the phonemic contrast and CDI score at 9 and 12 months of age. The HRF typicality score significantly correlated with KSPD language-social score. To control for possible effects of gestation, birth weight and corrected gestational age on the HRF typicality score, we performed partial correlation analyses. As a result, the correlation between HRF typicality score for phonemic contrast and CDI score at 12 months of age remained statistically significant. These results indicate that neonatal cerebral sensitivity to phonemic differences, but not prosodic differences, could predict language development at 12 months of age. This suggests that we could utilize this type of neural marker to screen for possible language delays in neonates.