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Pain, Itch and Their Disorders

開催日 2014/9/11
時間 11:00 - 12:00
会場 Poster / Exhibition(Event Hall B)

Peripheral nerve injury activates convergent nociceptive input to dorsal horn neurons from neighboring intact nerve

  • P1-189
  • 寺山 隆司 / Ryuji Terayama:1 山本 祐也 / Yuya Yamamoto:1,2 岸本 宣子 / Noriko Kishimoto:1,2 丸濵 功太郎 / Kotaro Maruhama:1 水谷 雅英 / Masahide Mizutani :1,2 飯田 征二 / Seiji Iida:1,2 杉本 朋貞 / Tomosada Sugimoto:1 
  • 1:岡山大院医歯薬口腔機能解剖 / Dept of Oral Funct and Anat, Okayama Univ Grad Sch Med, Dent and Pharmaceu Sci, Okayama, Japan 2:岡山大院医歯薬顎口腔再建外科 / Dept of Oral and Maxillofac Reconst Surg, Okayama Univ Grad Sch Med, Dent and Pharmaceu Sci, Okayama, Japan 

Previous studies demonstrated that peripheral nerve injury induced excessive nociceptive response of the spinal cord dorsal horn neurons and such change has been proposed to reflect the development of neuropathic pain state. The aim of this study was to examine the spinal dorsal horn for convergence of nociceptive input to second order neurons deafferented by peripheral nerve injury. Double immunofluorescence labeling for c-Fos and phosphorylated extracellular signal-regulated kinase (p-ERK) was performed to detect convergent synaptic input to the spinal dorsal horn neurons after the saphenous nerve injury. c-Fos expression and the phosphorylation of ERK were induced by noxious heat stimulation of the hindpaw and by electrical stimulation (ES) of the injured or uninjured saphenous nerve, respectively. Within the central terminal field of the saphenous nerve, the number of c-Fos-like immunoreactive (Fos-LI) cell profiles was significantly decreased at 3 days and returned to the control level by 14 days after the injury. p-ERK-LI cell profiles were distributed in the central terminal field of the saphenous nerve and the topographic distribution pattern and number of such p-ERK-LI cell profiles remained unchanged after the nerve injury. The time course of changes in the number of double-labeled cell profiles was similar to that of Fos-LI cell profiles after the injury. These results indicate that convergent primary nociceptive input through neighboring intact nerves contributes to increased responsiveness of the spinal dorsal horn nociceptive neurons.

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