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演題詳細

Symposium

脳神経回路の相互作用による行動の統合機能
Integrative function of higher-order behaviors through interaction of brain neural circuitry

開催日 2014/9/11
時間 17:00 - 19:00
会場 Room B(501)
Chairperson(s) 喜田 聡 / Satoshi Kida (東京農業大学 応用生物科学部バイオサイエンス学科 / Department of Bioscience, Tokyo University of Agriculture, Japan)
小林 和人 / Kazuto Kobayashi (福島県立医科大学 医学部 生体機能研究部門 / Department of Molecular Genetics, Fukushima Medical University, Japan)

行動の選択と柔軟性を制御する視床線条体システム
Thalamostriatal system that regulates response selection and flexibility

  • S1-B-3-5
  • 小林 和人 / Kazuto Kobayashi:1 加藤 成樹 / Shigeki Kato:1 
  • 1:福島県立医大・医・生体機能 / Dept Mol Genet, Fukushima Med Univ, Fukushima, Japan 

The basal ganglia circuitry plays important roles in the appropriate selection and flexible switching of behaviors. The dorsal striatum, a key structure of the basal ganglia circuitry, receives excitatory inputs from the central lateral nucleus (CL) and parafascicular nucleus (PF) localized in the rostral and caudal regions of the intralaminar thalamic nuclei in rodents, respectively. The anatomical and physiological properties of thalamostriatal neurons have been characterized, but their behavioral roles remains unclear. We address the roles of the thalamostriatal pathways originating from the PF and CL in learning processes of sensory discrimination task, by using selective neural pathway targeting. In this technique, the immunotoxin receptor is expressed in target pathways by the highly efficient retrograde gene transfer vector, and then the pathway is removed by immunotoxin reaction. The elimination of the PF-derived thalamostriatal pathway impairs the accuracy of response selection and delays the response in the acquisition phase of visual discrimination. This pathway elimination also impairs the response selection accuracy, persisting normally the response time in the performance phase. In contrast, the elimination of CL-derived thalamostriatal pathway does not influence the acquisition of visual discrimination, whereas it disturbs the selection accuracy and lengthens the response time. Therefore, these two thalamostriatal pathways have distinct roles in the acquisition and performance of sensory discrimination learning. These data suggest that the neural circuitry involved in sensory discrimination shifts during the learning processes. In addition, selective targeting of the CL-derived thalamostraital pathway impairs reversal learning of response discrimination, suggesting that this pathway contributes to the control of behavioral flexibility, which requires the prefrontal cortex-basal ganglia circuitry.

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