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開催日 2014/9/11
時間 16:00 - 17:00
会場 Poster / Exhibition(Event Hall B)

Mossy fiber activity in the cerebellar hemisphere during a step-tracking movement task with random delay period

  • P1-136
  • 石川 享宏 / Takahiro Ishikawa:1 戸松 彩花 / Saeka Tomatsu:2 筧 慎治 / Shinji Kakei:1 
  • 1:公益財団法人 東京都医学総合研究所 / Tokyo Metropolitan Inst. of Med. Sci., Tokyo, Japan 2:独立行政法人 国立精神・神経医療研究センター 神経研究所 / Inst. of Neurosci, National Ctr. of Neurology and Psychiatry, Tokyo, Japan 

Hemispheric part of the cerebellum receives its primary inputs from cerebral cortices via pontine nuclei, and therefore is called cerebrocerebellum. The ponto-cerebellar projection terminates as mossy fibers (MFs) in the granular layer in the cerebellar cortex. MFs in a part of the cerebrocerebellum (lobules IV-VI) predominantly originate from the primary motor cortex (M1) and premotor cortex (PM) (Kelly and Strick, 2003). Because of this anatomical structure, a pattern of MF activity in the cerebrocerebellum is thought to be a key component to understand what information the cerebral motor cortices provide to the cerebellum to make a movement. However, there have been no previous reports investigating the MF activity in behaving monkeys. We therefore examined unit activity of MFs in the cerebrocerebellum during a step-tracking movement task with random delay period (1-2 sec) in 2 monkeys. We recorded 155 MFs showing significant task-related activity, and compared their activity with the activity in M1 and PM neurons recorded during the same task in our previous studies (Kakei et al., 1999, 2001). As a result, we found that there are several common patterns of task-related activity between MFs and M1/PM neurons. First, 70 MFs showed prolonged modulation change between instruction cue presentation and go signal, i.e. delay period. Second, all of 155 MFs showed phasic or tonic modulation change at movement onset as often observed in M1/PM neurons. Third, a large part of MFs were directionally tuned in delay period (n=57) and/or at movement onset (n=120). After all, we found that patterns of task-related activity in M1/PM neurons were preserved in MF activity in the cerebrocerebellum. This result indicates that the cerebellum receives efference copy of motor cortical activity that can serve to predict results of an action. Furthermore, considering that many MFs showed delay activity, the cerebellum may be involved in not only movement execution but also planning or preparation for upcoming movement.

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