• Top page
  • Timetable
  • Per session
  • Per presentation
  • How to
  • Meeting Planner



Sensory-input dependent refinement of neural circuits

開催日 2014/9/12
時間 15:00 - 17:00
会場 Room G(303)
Chairperson(s) 久場 博司 / Hiroshi Kuba (名古屋大学大学院医学系研究科細胞生理学 / Department of Cell Physiology, Nagoya University, Japan)
宮田 麻理子 / Mariko Miyata (東京女子医科大学・医学部・第一生理学教室 / Department of Physiology,Tokyo Women's Medical University, Japan)

Molecular mechanism of sensory experience-dependent maintenance of neuronal circuits

  • S2-G-1-1
  • 宮田 麻理子 / Mariko Miyata:1,5 鳴島 円 / MADOKA NARUSHIMA:1 内ヶ島 基政 / Motokazu Uchigashima:2 橋本 浩一 / Kouichi Hashimoto:3 原田 武志 / Takeshi Harada:4 饗場 篤 / Atsu Aiba:4 渡辺 雅彦 / Masahiko Watanabe:2 狩野 方伸 / Masanobu Kano:5,6 
  • 1:東京女子医科大学・医学部・第一生理学教室 / Dept.of Physiology,Tokyo Women's Medical Univ., Japan 2:北海道大院医解剖発生 / Dept Anatomy, Grad Sch Med, Hokkaido Univ, Sapporo, Japan 3:広島大院医歯薬神経生理 / Dept Neurophysiol, Grad Sch Biomed & Health Sci, Hiroshima Univ, Hiroshima, Japan 4:東京大院医疾患生命工学動物資源学 / Lab Animal Resources, CDBIM, Sch Med, Univ Tokyo, Tokyo, Japan 5:JSTさきがけ / PRESTO, JST, Kawaguchi, Japan 6:東京大院医神経生理 / Dept Neurophysiol, Grad Sch Med, Univ Tokyo, Tokyo, Japan 

Sensory experience plays a crucial role in stabilizing and maintaining precise neuronal circuits. However, its molecular mechanism remains poorly understood. Recently, we discovered that the expression of type 1 metabotropic glutamate receptor (mGluR1) in the mouse dorsal lateral geniculate nucleus (dLGN) increased dramatically after the eye opening (P14~). Thus, we hypothesized that mGluR1 was involved in visual experience-dependent maintenance of the retinogeniculate (RG) synapse. We found that the developmental strengthening and elimination of RG synapses in mGluR1-KO mice were completed normally by the third postnatal week, indicating that mGluR1 is not involved in the initial phase of RG synaptic development. However, during the subsequent visual experience-dependent maintenance phase (P20~), RG synaptic innervations became aberrant in both mGluR1-KO mice and wild type mice whose mGluR1 was blocked in dLGN even under normal visual experience: weak RG synaptic fibers were newly recruited onto a single thalamic neuron. This phenomenon closely resembles the synaptic remodeling of RG fibers driven by the late visual deprivation from P20 to P28. Most notably, we found that this visual deprivation-mediated remodeling did not take a place in mGluR1-KO mice. These results suggest that mGluR1 in dLGN stabilizes once established RG synapses in a visual experience-dependent manner.

Copyright © Neuroscience2014. All Right Reserved.