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演題詳細

Poster

学習・長期記憶
Learning and Long-term Memory

開催日 2014/9/12
時間 11:00 - 12:00
会場 Poster / Exhibition(Event Hall B)

大脳皮質神経細胞におけるmemory allocationの分子基盤
Memory allocation in the sensory cortex

  • P2-243
  • 佐野 良威 / Yoshitake Sano:1 Shobe Justin L / Justin L Shobe:1 Zhou Miou / Miou Zhou:1 Huang Shan / Shan Huang:1 Shuman Tristan / Tristan Shuman:2 Cai Denise J / Denise J Cai:1 Golshani Peyman / Peyman Golshani:2 Kamata Masakazu / Masakazu Kamata:3 Silva Alcino J / Alcino J Silva:1 
  • 1:Departments of Neurobiology, Psychiatry & Biobehavioral Sciences, Psychology, Integrative Center for Learning and Memory and Brain Research Institute, University of C / Departments of Neurobiology, Psychiatry & Biobehavioral Sciences, Psychology, Integrative Center for Learning and Memory and Brain Research Institute, University of California, Los 2:Department of Neurology at David Geffen School of Medicine, University of California, Los Angeles, CA, USA. / Department of Neurology at David Geffen School of Medicine, University of California, Los Angeles, CA, USA 3:Department of Hematology and Oncology, University of California, Los Angeles, CA, USA. / Department of Hematology and Oncology, University of California, Los Angeles, CA, USA 

The mechanism of memory storage has been extensively studied, especially in the hippocampus and amygdala, however, we know very little about how specific population of neurons in these brain areas are selectively recruited as part of the memory storage cells. This phase of memory formation is referred to as "memory allocation". Recent findings suggest that that cAMP response element binding protein (CREB) is involved in the mechanism of memory allocation in amygdala. While we have found the mechanisms of fear memory allocation in the amygdala, we do not know how allocation works in other brain areas. This research focuses on understanding the mechanism of memory allocation in the sensory cortex, where properties of cellular and circuit organization are different from the amygdala. We hypothesized that specific population of neurons is selectively recruited as memory cells and CREB is involved in this mechanisms. To address this hypothesis, we have developed lentivirus to express CREB and hM4Di in same excitatory neurons. hM4Di receptor is only activated by synthesized ligand (CNO) which result in hyperpolarization of neurons. We have focused on the insular cortex which is a critical structure for memory formation of conditioned taste aversion (CTA). Here, we show that taste memory is preferentially recruited into neurons with higher level of CREB in the insular cortex. And our results suggest that mechanism of memory allocation is very general in the brain which is composed of heterogeneous neuronal basis.

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