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Neurodevelpmental Disorders and Schizophrenia

開催日 2014/9/13
時間 9:00 - 10:00
会場 Room I(311+312)
Chairperson(s) 内匠 透 / Toru Takumi (独立行政法人理化学研究所 / RIKEN Brain Science Institute, Japan)
神尾 陽子 / Yoko Kamio (国立精神・神経医療研究センター 精神保健研究所 児童・思春期精神保健研究部 / Department of Child and Adolescent Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry, Japan)

Effects of long-term oxytocin administration on functional connectivities with default mode network in autism spectrum disorder

  • O3-I-1-2
  • 小坂 浩隆 / Hirotaka Kosaka:1,2,8 丁 ミンヨン / Jung Minyoung:1,2,3 齋藤 大輔 / Daisuke N Saito:1,2 石飛 信 / Makoto Ishitobi:1,4 猪原 敬介 / Keisuke Inohara:1,5 新井 清義 / Sumiyoshi Arai:1,2 升谷 泰裕 / Yasuhiro Masuya:1 藤岡 徹 / Tohru Fujioka:1 岡本 悠子 / Yuko Okamoto:1,2 棟居 俊夫 / Toshio Munesue:2,6 友田 明美 / Akemi Tomoda:1,2 佐藤 真 / Makoto Sato:1,2 定藤 規弘 / Norihiro Sadato:7 岡沢 秀彦 / Hidehiko Okazawa:1,2 和田 有司 / Yuji Wada:1,2 
  • 1:福井大・子どものこころの発達研究センター / Res Center Child Mental Develop, Univ. of Fukui, Japan 2:大阪大・連合小児発達学研究科 / United Graduate School of Child Develop, Osaka Univ, Fukui, Japan 3:日本学術振興会 / JSPS, Japan 4:国立精神・神経セ精神保健研 / NCNP, Japan 5:電気通信大 / Univ of Electro-Communications, Japan 6:金沢大・子どものこころの発達研究センター / Kanazawa Univ, Japan 7:生理学研究所 / NIPS, Japan 8:福井大・精神 / Dept Neuropsychi, Univ of Fukui, Japan 

Objectives: Recent studies suggest that single dose intranasal oxytocin lead to enhance emotional recognition and increase eye gaze, and intranasal oxytocin is a promising candidate treatment of social impairments of patients with autism spectrum disorder (ASD). Neuroimaging studies also identified that single dose intranasal oxytocin changed brain activation in medial prefrontal cortex (MPFC), middle frontal gyrus (MFG), and amygdala during social cognition processing in individual with ASD. However, to date, there have been no attempts to investigate the effects of long-term intranasal oxytocin of daily administration. In the current study, we tested the effect of long-term intranasal oxytocin on the resting-state functional connectivity (rs-FC) with the default mode network (DMN).
Methods: In a randomized, double-blind, placebo-controlled clinical trial, ten individuals with ASD received intranasal oxytocin or placebo. Resting-state functional MRI before and after long-term oxytocin administration were used to investigate the alteration of rs-FC with DMN. Repeated measures analysis of variance (ANOVA) was applied to identify brain regions exhibiting a predicted treatment Χ time interaction.
Results: The result of ANOVA shows interaction between treatment and time in rs-FC between angular gyrus with anterior medial prefrontal cortex (aMPFC). We also found the degree of change of rs-FCs between angular gyrus with aMPFC are associated with Clinical Global Impressions - Improvement (CGI-I) scales.
Conclusion: These findings reveal a unique process underlying the effects of long term intranasal oxytocin. Interestingly, these regions largely overlap with the language and semantic processing. This is the first evidence of the effects of long-term intranasal oxytocin administration on communication within social cognition processing.

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