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Voluntary Movements

開催日 2014/9/13
時間 17:10 - 18:10
会場 Room H(304)
Chairperson(s) 小池 康晴 / Yasuharu Koike (東京工業大学 / Tokyo Institute of Technology, Japan)
筒井 健一郎 / Ken-ichiro Tsutsui (東北大学大学院生命科学研究科 脳情報処理分野 / Division of Systems Neuroscience, Graduate School of Life Sciences, Tohoku University, Japan)

Internal model mechanisms of slow and fast prism adaptation in human hand-reaching movement

  • O3-H-5-3
  • 本多 武尊 / Takeru Honda:1 永雄 総一 / Soichi Nagao:1,2,3 橋本 祐二 / yuji Hashimoto:1 石川 欽也 / Kinya Ishikawa:1 水澤 英洋 / Hidehiro Mizusawa:1 伊藤 正男 / Masao Ito:2 
  • 1:東京医科歯科大院・医・脳神経病態 / Dept Neurol, Tokyo Med Dent Univ, Japan 2:理研・脳センター / RIKEN BSI, Japan 3:のぞみ高次脳機能研究所 / Nozomi Higher Brain Function Laboratory, Japan 

Internal model mechanisms of slow and fast prism adaptation in human hand-reaching movement

Takeru Honda1,2,3, Soichi Nagao1,2,3, Yuji Hashimoto1, Kinya Ishikawa1, Hidehiro Mizusawa1, Masao Ito2

1Dept of Neurol, Tokyo Med Dent Univ, Tokyo,
2RIKEN BSI, Saitama, Japan
3Nozomi Higher Brain Function Laboratory, Saitama

Updating the internal model of movement memorized in the brain is necessary for subtle and precise motor control. We modified the protocol of human prism adaptation of hand-reaching movement to clarify how an internal model is updated during learning of voluntary movement. In our protocol, participants wore the goggle mounting the Fresnel prism which shifts visual field 25 deg rightward and were requested to reach their right index finger to the target presented on a touchscreen either in offline feedback or non-feedback mode. The electrical shutter attached to the goggle prevented the participants from seeing both the finger and target during hand-reaching motion in both modes. In feedback mode, as soon as the subject touched the screen the shutter was reopened for one second so that the subjects confirmed the deviation. In non-feedback mode, on the other hand, the shutter was kept closed. During 100 hand-reaching trials in offline feedback mode, healthy subjects (n=5) became able to adapt to the prism plate, while patients with cerebellar diseases (n=10) exhibited impaired adaptation. Next, when the other five healthy subjects repeated alternation between 10 trials in offline feedback mode and 5 trials in non-feedback mode, up to 210 trials, they rapidly became able to correctly touch the target in offline feedback mode (fast adaptation), whereas they spent many more trials to correctly touch the target in non-feedback mode (slow adaptation). These observations suggest that two types of adaptation, fast and slow, represent different internal model mechanisms of prism adaptation in the cerebellum.

[Grant in aid for Strategic Research Program for Brain Sciences]

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