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開催日 2014/9/13
時間 14:00 - 15:00
会場 Poster / Exhibition(Event Hall B)

Behavioral Responses to Chronic Restraint Stress in Mice Lacking Phospholipase C-related Inactive Protein Type-1

  • P3-186
  • 二階堂 義和 / Yoshikazu Nikaido:1 下山 修司 / Shuji Shimoyama:2 尾崎 拓 / Taku Ozaki:2 右田 啓介 / Keisuke Migita:3 柴 祐子 / Yuko Shiba:3 古川 智範 / Tomonori Furukawa:3 山田 順子 / Junko Yamada:4 兼松 隆 / Takashi Kanematsu:5 平田 雅人 / Masato Hirata:6 中村 和彦 / Kazuhiko Nakamura:2,7 上野 伸哉 / Shinya Ueno:2,3 
  • 1:弘前大院医  / Hirosaki Univ Grad Sch Med, Hirosaki, Japan 2:弘前大院医 子どものこころの発達研究センター  / Res Cent Child Ment Dev, Hirosaki Univ, Hirosaki, Japan 3:弘前大院医 脳神経生理 / Dept Neurophysiol, Hirosaki Univ, Hirosaki, Japan 4:弘前大院保 生体機能 / Dept Biomed Sci, Div Med Life Sci, Hirosaki Univ, Hirosaki, Japan 5:広島大院医歯薬 歯科薬理 / Dept Dent Pharmcol, Hiroshima Univ, Hiroshima, Japan  6:九州大院歯 口腔細胞工学 / Lab Mol Cell Biochem, Univ of Kyushu, Fukuoka, Japan 7:弘前大院医 神経精神 / Dept Neuropsychi, Hirosaki Univ, Hirosaki, Japan 

Phospholipase C-related inactive protein type-1 (PRIP-1) modulates inhibitory neurotransmission by regulating the trafficking and phosphorylation of GABAA receptors in the central nervous system. Dysregulation of GABAA receptors is known to be responsible for anhedonia, depression and anxiety seen in stress-induced disorder such as major depressive disorder. However, it remains unknown that PRIP-1 has a critical role in anhedonia, depression and anxiety. In the present study, we investigated whether PRIP-1 deficiency affect chronic restraint stress (CRS)-induced behaviors using several anhedonic, depressive- and anxiety-related models (eg, the sucrose preference test for testing anhedonia-like behavior; the forced swim test (FST) for depressive-like behavior; the open field test (OF), the elevated-plus maze test (EPM) and the social interaction test (SI) for anxiety-like behavior). CRS induced a prolonged decrease in sucrose preference in wild-type (WT) mice. Interestingly, PRIP-1 knockout (PRIP-1 KO) mice subjected to CRS exhibited a transient but not prolonged decrease in sucrose preference. In the FST after CRS, PRIP-1 KO mice displayed less immobility than WT mice. In addition, CRS-exposed PRIP-1 KO mice showed a lower level of anxiety-like behavior in the OF, EPM and SI than those WT mice. These results indicate that PRIP-1 KO mice did not exhibit CRS-induced long-lasting anhedonic, depressive- and anxiety-like states. PRIP-1-mediated GABAergic transmission might be involved in the development of stress-induced behavioral changes.

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