演題詳細
Poster
統合失調症者のフィードフォワード運動制御の障害
Impairment of feed-forward motor control in patients with schizophrenia
- P1-367
- 菊池 ゆひ / Yui Kikuchi:1,2 米田 貢 / Mitsugu Yoneda:1 越後 亮介 / Ryosuke Echigo:1 中川 紗佑里 / Sayuri Nakagawa:1 小池 康晴 / Yasuharu Koike:3 少作 隆子 / Takako Ohno-Shosaku:1
- 1:金沢大学保健学系 / Fac. Health Sci. Kanazawa Univ., Kanazawa, Japan 2:金沢大学附属病院 / Kanazawa University Hospital 3:東京工業大学ソリューション研究機構 / P&I Lab, Tokyo Tech., Yokohama, Japan
The cerebellum plays an essential role in prediction-based, feed-forward motor control - which is important for performing movements smoothly, precisely, and skillfully. Patients with schizophrenia have a wide range of motor symptoms, and display functional and morphological abnormalities of the cerebellum. There is an attractive hypothesis suggesting that a disruption in the connectivity involving the cerebellum produces "cognitive dysmetria", and can account for a broad diversity of symptoms in schizophrenia. The purpose of this study is to test the possibility that feed-forward motor control is impaired in schizophrenia, by comparing predictive components of hand movements during a weight-loading task between 10 healthy volunteers and 10 patients with schizophrenia. We monitored the vertical deflection of the hand when a downward force (4.9 N) was applied to the right hand (loading) using by a haptic device named the Space Interface Device for Artificial Reality (SPIDAR), which enables us to perform a ball-catching or weight-loading task in a virtual environment. The hand movement was also monitored by the accelerometer attached to the dorsal surface of the right hand. Loading was started by pressing a start key, which was pressed by either the subject (predictable condition) or an examiner (unpredictable condition). To assess feed-forward motor control, we measured the upward movement just before the start of loading. This upward movement (anticipatory response) was observed only in the predictable condition, confirming that it is based on prediction. We found that the amplitude of anticipatory response was significantly smaller in the patients than in the healthy volunteers. We also found that the amplitude of anticipatory response was negatively correlated with age in both the healthy and patient groups. These results show that feed-forward motor control is impaired in patients with schizophrenia, and that aging might exaggerate the impairment. Our results are consistent with the ''cognitive dysmetria'' hypothesis that emphasizes the role of the cerebellum in schizophrenia.