演題詳細
Poster
脊髄、運動細胞、筋肉
Spinal cord Motor Neurous and Muscle
| 開催日 | 2014/9/11 |
|---|---|
| 時間 | 16:00 - 17:00 |
| 会場 | Poster / Exhibition（Event Hall B） |
サル頸髄硬膜下電気刺激による誘発運動の体部位局在性
Somatotopical Arrangement of Stimulus Outputs Induced by Subdural Micro-Stimulation on Cervical Spinal Cord in Monkeys
- P1-118
- 加藤 健治 / Kenji Kato:1 西村 幸男 / Yukio Nishimura:1,2,3
- 1:自然科学研究機構 生理学研究所 認知行動発達機構研究部門 / Division of Behavioral Development, National Institute for Physiological Sciences, Aichi, Japan 2:総合研究大学院大学 生命科学研究科 / The graduate University for Advanced studies, SOKENDAI, Aichi, Japan 3:科学技術振興機構 さきがけ / Precursory Research for Embryonic Science and Technology (PRESTO), Japan Science and Technology Agency, Tokyo, Japan
Somatotopical Arrangement of Stimulus Outputs Induced by Subdural Micro-Stimulation on Cervical Spinal Cord in Monkeys
Kenji Kato, Yukio Nishimura
National Institute for Physiological Sciences, National Institutes of Natural Sciences
Spinal stimulation is a promising method for reanimating of function in paralyzed limbs following neurological damages in descending pathways. Although intraspinal stimulation through the chronically-implanted electrode is capable of evoking a variety of highly-functional movements, they face limitations such as tissue damages due to the surgical implant, deterioration of stimulus outputs due to electrode encapsulation. Subdural microstimulation on the spinal cord (SMSS) is an alternative approach to less invasive stimulation method. Here we examine the forelimb movements and muscle responses evoked by cervical SMSS in monkeys sedated or during arm-reaching task. We chronically implanted a platinum subdural electrode array over the dorsal-lateral aspect of cervical spinal cord, which had 8 channels placed at the level between C5 and T1. Trains of three stimulus pulses (271±97 μA) at 200 Hz were delivered at sites under monkeys sedated. The evoked movements clearly showed somatotopic map of output sites, the electrode locates on rostral cervical cord tended to induce movements in proximal arm whereas caudal one tended to induce distal movements such wrist and digits. To document the muscle responses evoked by SMSS, the stimulus-triggered averaging of rectified EMG during monkeys' performing arm-reaching task were compiled. Typically, SMSS evoked facilitation or suppression effects in multiple muscles which including both proximal and distal joints with synergistic muscle responses, but little somatotopic organization. These results indicate that less-invasive SMSS offers an alternative method to drives residual spinal circuits produce coordinated and functional movement, suggesting future strategies for neuroprosthetic technology to regain the functional loss after damage in descending pathways.