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Kinematics and EMG

開催日 2014/9/11
時間 11:00 - 12:00
会場 Poster / Exhibition(Event Hall B)

Rewiring the damaged pathway via neural interface to restore volitional walking in spinal cord injury

  • P1-115
  • 笹田 周作 / Syusaku Sasada:1,2 加藤 健治 / Kenji Kato:2 中尾 弥起 / Yaoki Nakao:2,3 村山 尊司 / Takashi Murayama:4 門脇 傑 / Suguru Kadowaki:5 吉田 晋 / Susumu Yoshida:6 飯塚 正之 / Masayuki Iizuka:4 小宮山 伴与志 / Tomoyoshi Komiyama:7 宇川 義一 / Yoshikazu Ugawa:5 西村 幸男 / Yukio Nishimura:2,3,8 
  • 1:相模女子大学 / Sagami Women's Univ., Kanagawa, Japan 2:自然科学研究機構生理学研究所発達生理学研究系 / Developmental Physiology, National Inst. for Physiological Sciences, Aichi, Japan 3:総合研究大学院大学生命科学研究科 / Life Science, The Graduate Univ. for Advanced Studies, Aichi, Japan 4:千葉県千葉リハビリテーションセンター / Chiba Rehabilitation Center, Chiba, Japan 5:福島県立医科大学医学部神経内科学講座 / Dept. of Neurology, Fukushima Medical Univ., Fukushima, Japan 6:北海道医療大学リハビリテーション科学部 / School of Rehabilitation Sciences, Health Sciences Univ. of Hokkaido, Hokkaido, Japan 7:千葉大学教育学部 / Faculty of Education, Chiba Univ, Chiba, Japan 8:科学技術支援機構さきがけ / PRESTO, Japan Science and Technology Agency, Tokyo, Japan 

Gait disturbance in individuals with spinal cord injury is attributed to interruption of descending pathways to spinal locomotor network, although neural circuits locate below and above the lesion remain most their function. An artificial neural connection that bridges supra-spinal centers and locomotor network in lumbar spinal cord beyond the lesion site might have potential to restore the functional loss. Here we show that an artificial neural connection that delivers the descending command associated with arm muscle activity can induce volitional walking-like behavior of paralysis legs in individuals with a complete spinal cord injury (SCI).
Two individuals with a complete SCI were participated in the present study. The lesion sites in two individuals were Th12 and Th3 respectively. According to neurological criteria and the ASIA classification, they were classified as complete SCI and ASIA A category with no motor and sensory function below the lesion site. The artificial neural connection was produced by a brain-computer interface that detects the activity pattern of hand muscle and to deliver hand muscle activity-dependent non-invasive magnetic stimuli over the lumbar spinal cord.
Walking behavior in paralysis legs could be induced via artificial neural connection. Individuals were able to control start/stop and step cycle of the behavior. This behavior was not seen while the artificial neural connection was terminated even when the subject continued hand muscle contraction.
These results suggest that the walking behavior in paralysis legs could be controlled volitionally via the artificial neural connection. This paradigm was useful to regain volitional walking in individuals with complete SCI.

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