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演題詳細

Poster

体性感覚
Somatosensory System

開催日 2014/9/13
時間 11:00 - 12:00
会場 Poster / Exhibition(Event Hall B)

視覚剥奪ラットの体性感覚野における側方抑制の強化
Visual deprivation enhances lateral inhibition in the rat barrel cortex

  • P3-151
  • 中島 和希 / Waki Nakajima:1 実木 亨 / Susumu Jitsuki: 高橋 琢哉 / Takuya Takahashi: 
  • 1:横浜市大・医・生理 / Yokohama City University, Graduate School of Medicine, Department of Physiology 

Loss of one type of sensory input can cause improved functionality of other sensory systems. This form of plasticity, cross-modal plasticity, is well established (Bavelier and Neville, 2002; Goel et al., 2006). We have previously shown that visual deprivation (VD) induces trafficking of the AMPA-type glutamate receptors into layer 4 to layer 2/3 synapses (Jitsuki et al., 2011). VD leads to sharpening of the functional whisker-barrel map at layer 2/3. However, the mechanism maintaining sharpened functional whisker barrel map is still unclear.
In this study, we found that VD increases evoked miniature inhibitory postsynaptic current (evoked mIPSC) and IPSC/excitatory postsynaptic current (EPSC) ratio in the layer 2/3 to 2/3 synapses (lateral pathway), but not in the layer 4 to 2/3 (vertical pathway). Moreover, VD sharpened functional whisker-barrel map in layer 2/3 of the barrel cortex. These results indicate that VD enhances lateral inhibition and that maintains sharpened neural circuits in the barrel cortex.






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