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Basal Ganglia

開催日 2014/9/11
時間 11:00 - 12:00
会場 Poster / Exhibition(Event Hall B)

The topography of striatopallidal projections and calbindin immunoreactive subdivisions

  • P1-139
  • 水谷 和子 / Kazuko Mizutani:1 苅部 冬紀 / Fuyuki Karube:1 呉 胤美 / Yoon Mi Oh:1 中野 泰岳 / Yasutake Nakano:1 藤山 文乃 / Fumino Fujiyama:1,2 
  • 1:同志社大学大学院 脳科学研究科 神経回路形態部門 / Laboratory of Neural Circuitry, Grad Sch of Brain Science, Doshisha Univ 2:(独)科学技術振興機構 CREST / CREST, JST 

The basal ganglia (BG) include the striatum, the external segment of globus pallidus (GPe), subthalamic nucleus and the output nuclei of the BG. Based on the connectivity with the particular area of cerebral cortex, the cortico–basal ganglia–thalamo–cortical loop is likely processed independently via multiple, parallel, segregated circuits. On the other hand, immunohistochemistry for the calcium binding protein, calbindin–D28K (CB), shows the unique distribution pattern in the basal ganglia. CB stains many of the striatofugal neurons in the almost all area of matrix compartment of the striatum but not in the striosome compartment and the dorsolateral striatum. The GPe can be divided into three (rostral and caudal CB–immunopositive and medial CB–immunonegative) regions and the distribution of CB immunoreactivity in the GPe reflects the dual topographic representation of the striatopallidal projections. It means that the arrangement of the striatopallidal pathway follows not only the topography according to the cortical area but also the unique manner with neural divergence. In the present study, we examined the topography of striatopallidal projections by using a combination of retrograde labeling of striatopallidal neurons and CB immunohistochemistry. The micro injections of retrograde tracers into the CB–immunopositive and –negative subdivisions of the GPe produced the labeled cells in the CB–immunopositive and –negative striatum, respectively. Within each subdivision, the arrangement of labeled striatopallidal neurons follows the topography of the injection site in the GPe along the rostrocaudal and dorsoventral axes. Unexpectedly, the injection of retrograde tracers into the CB–immunopositive rostral and caudal subdivisions of the GPe showed slightly different distribution pattern of labeled cells, suggesting that the striatopallidal axons ramified their branches in two pallidal regions unevenly. These results show the complexity of anatomical architecture of the BG that serves as means for convergence or divergence of the information processing.

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