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Motivation and Emotion

開催日 2014/9/12
時間 14:00 - 15:00
会場 Poster / Exhibition(Event Hall B)

Effect of social buffering on fear extinction in male rats

  • P2-218
  • 三上 香織 / Kaori Mikami:1 清川 泰志 / Yasushi Kiyokawa:1 武内 ゆかり / Yukari Takeuchi:1 森 裕司 / Yuji Mori:1 
  • 1:東京大院・農・獣医動物行動学 / Lab of Vet Etholo, Univ of Tokyo, Tokyo, Japan 

In the fear extinction, fear responses to the conditioned stimulus (CS) are decreased after extinction training. The stress during extinction training appears to be one of the factors that affect the efficacy of extinction training. We have reported in male rats that the presence of a conspecific (associate) induce "social buffering" and mitigate stress responses to the CS. Based on these findings, we have hypothesized that social buffering during the extinction training enhances the efficacy of extinction training. To examine this hypothesis all the subjects received 7 repetitions of a 3-sec tone (8kHz, 70dB) that terminated concurrently with a 0.5-sec foot shock (0.55mA) during the conditioning procedure on day 1. On day 2, the subject of the alone-training group was placed in a test box and underwent the extinction training during which only the CS was presented 24 times at random intervals varying from 1 to 2-min. In addition, we prepared the alone-non-training group that was kept in the test box for the same period but never exposed to the CS. The subjects of the social-training and social-non-training groups were treated in a similar manner with one exception that they were placed in the test box with a non-conditioned associate. On day 3, the subject of each group was placed in the test box alone and was exposed to the CS twice. The ratio of freezing during the first 20-sec after the onset of each CS was calculated and expressed as the average of two responses. On day 1, the conditioning procedure increased the intensity of freezing to the CS. However, on day 2, the freezing of the alone-training group was gradually decreased during extinction training, and social buffering suppressed the freezing throughout the training in the social-training group. On day 3, the freezing of the alone-training group was equivalent with those of the alone-non-training group, suggesting that extinction training conducted in this study was not sufficient to suppress freezing on day 3, whereas freezing of the social-training group was decreased as compared to those of the social-non-training group. These results suggest that social buffering enhances the efficacy of extinction training.

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