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演題詳細

Symposium

Sculpting the neuronal intracellular environment: from single molecule behavior to local signal integration
Sculpting the neuronal intracellular environment: from single molecule behavior to local signal integration

開催日 2014/9/12
時間 9:00 - 11:00
会場 Room B(501)
Chairperson(s) 合田 裕紀子 / Yukiko Goda (理化学研究所 脳科学総合研究センター シナプス可塑性・回路制御研究チーム / RIKEN, Brain Science Institute, Japan)
瀬藤 光利 / Mitsutoshi Setou (浜松医科大学 解剖学講座 細胞生物学分野 / Department of Cell Biology and Anatomy Hamamatsu University School of Medicine, Japan)


Balancing synaptic strengths across the dendritic tree

  • S2-B-1-1
  • 合田 裕紀子 / Yukiko Goda:1 Letellier Mathieu / Mathieu Letellier: 
  • 1:理化学研究所 / RIKEN, Brain Science Institute, Japan 

Use-dependent changes in synaptic strength play a fundamental role in shaping synaptic connections during development and provide a cellular basis for cognitive functions in the mature brain. Mounting epidemiological and genetic evidence highlight synaptic dysfunctions in the etiology and progression of a broad range of neurological disorders, and this underscores the central importance of synaptic processing. Each principal neuron in the brain receives many thousands of synaptic connections. Whereas synapses are functionally autonomous, nearby synapses strongly interact, and therefore, in deciphering how neural circuits exploit synaptic plasticity to encode and decode information, it is crucial to understand how synapses influence each other in adjusting their strengths. Using a combination of electrophysiology and imaging approaches we have investigated how synaptic strengths are dynamically distributed across the dendritic tree of hippocampal pyramidal neurons. We find that, surprisingly, postsynaptic strengths are homogeneous and cannot be discriminated between different inputs. In contrast, presynaptic strengths are distinct between convergent inputs targeting the same postsynaptic neuron, and inducing synaptic plasticity in one input triggers a compensatory change in the presynaptic strength of a non-stimulated input. We provide evidence for a novel cellular mechanism in balancing synaptic strengths across different synaptic connections.

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