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演題詳細

Poster

嗅覚、味覚、化学感覚
Olfaction, Taste, Chemical Senses

開催日 2014/9/13
時間 11:00 - 12:00
会場 Poster / Exhibition(Event Hall B)

体重によるショ糖嗜好性制御メカニズムにおける扁桃体と体性感覚野(S1FL/HL)の関係
Relationship between amygdala and somatosensory cortex for limbs (S1FL/HL) in regulation of sucrose preference by body weight

  • P3-141
  • 朝比奈 洋子 / Yoko Asahina:1 藤原 宏子 / Hiroko Eda-Fujiwara:2 佐藤 亮平 / Ryohei Satoh:3 八十島 安伸 / Yasunobu Yasoshima:4 宮本 武典 / Takenori Miyamoto:1 
  • 1:日本女子大・院理・物質生物機能・生体情報科学 / Lab Behav Neurosci, Div Biol Sci, Grad Sch Sci, Japan Women's Univ, Tokyo, Japan 2:人間総合科学大・人間科学・人間科学 / Dept of Human Arts Sciences, Univ of Human Arts and Sciences, Saitama, Tokyo 3:北里大学・医・生理 / Dept Physiol, Sch Med, Kitasato Univ, Kanagawa, Japan 4:大阪大学・院人間科学・行動生理 / Div Behav Physiol, Dept of Behav Sci, Grad Sch of Human Sci, Osaka Univ, Osaka, Japan 

In our previous studies, food-restricted mice preferred high-caloric sweetener sucrose (Suc), and amygdala lesions inhibited the Suc preference. Mice consumed high-caloric Suc rather than non-caloric sodium saccharin (Sac), when their body weight (BW) of mice reduced to 75% of the original BW for 3 to 6 days by chronic food-restriction. However, Suc consumption abruptly dropped to Sac consumption levels (Saltatory Suppression of Suc Preference; SSSP) immediately after the regain their original BW. The SSSP tended to be suppressed by lesions of somatosensory area for the limbs (S1FL/HL). In the present experiment, we examined the expression of a neuronal activity marker c-Fos in amygdala and S1FL/HL to clarify the relationship between those brain regions. The number of c-Fos positive cells in amygdala of pre-SSSP group was significantly higher than that of post-SSSP group. In contrast, the number of c-Fos positive cells in S1FL/HL of pre-SSSP group was lower than that of post-SSSP group. These results suggest that the sensory activation of S1FL/HL encoding increment of BW decreases amygdala function, resulting in suppression of Suc preference.

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