We often have opportunity to drink alcohol, known to inhibit and slow down our cognitive and motor activity if taken excessively, in our daily life. There has been a number of cognitive and motor studies in relation to drinking alcohol and the results from those studies are consistent with what we experience in our life. However, there is still only a few studies that concerned choice reaction time, the time between a stimulus given in a certain position and reaction of the corresponding effector, with different types of stimuli in within-subject design. Further, the choice reaction time task is known to require more complex brain activity compared with the simple reaction time task. In the present study, we examined the effect of drinking alcohol on spatial cognition using choice reaction time task under violation of spatial cognition, that is, under which subjects were required to use contralateral hand to the side of stimulus to respond, or, the subjects' hands were crossed so that ipsilateral hand to the side of stimulus was placed on the contralateral side with respect to the body center. Using visual, auditory and tactile stimuli, our results showed that the significantly slowed reaction time and lowered success rate as the alcohol concentration increased. Further, if subjects were required to respond with the contralateral hand to the stimuli or to execute task with their hands crossed, the reaction time and the success rate were significantly affected as the increase of alcohol concentration. These results were consistent with the previous studies and might be because more complex response is required, more alcohol affects.