演題詳細
Poster
アルツハイマー病、他の認知症、老化
Alzheimer's Disease, Other Dementia, Aging
| 開催日 | 2014/9/12 |
|---|---|
| 時間 | 11:00 - 12:00 |
| 会場 | Poster / Exhibition（Event Hall B） |
アポリポプロテインE4の健常青少年海馬の体積への影響
The influence of ApoE4 on hippocampal volume in healthy children and adolescents
- P2-287
- 國時 景子 / Keiko Kunitoki:1 橋本 照男 / Teruo Hashimoto:2 横田 晋務 / Susumu Yokota:2 橋爪 寛 / Hiroshi Hashizume:2 井上 健太郎 / Kentaro Inoue:3 竹内 光 / Hikaru Takeuchi:2,4 関口 敦 / Atsushi Sekiguchi:4,5 荒井 啓行 / Hiroyuki Arai:6 富田 博秋 / Hiroaki Tomita:7 川島 龍太 / Ryuta Kawashima:2,4,8 瀧 靖之 / Yasuyuki Taki:2,3,5
- 1:東北大学医学部 / Tohoku University School of Medicine 2:東北大学加齢医学研究所認知機能発達寄附研究部門 / Division of Developmental Cognitive Neuroscience, Institute of Development, Aging and Cancer, Tohoku University, Sendai 3:東北大学加齢医学研究所機能画像医学研究分野 / Department of Nuclear Medicine and Radiology, Institute of Development, Aging and Cancer, Tohoku University, Sendai 4:東北大学加齢医学研究所脳機能開発研究分野 / Department of Functional Brain Imaging, Institute of Development, Aging and Cancer, Tohoku University, Sendai 5:東北メディカル・メガバンク機構脳画像解析医学分野 / Division of Medical Neuroimage Analysis, Department of Community Medical Supports, Tohoku Medical Megabank 6:東北大学加齢医学研究所老年医学分野 / Department of geriatrics, Institute of Development, Aging and Cancer, Tohoku University, Sendai 7:東北大学災害科学国際研究所 / International Research Institute of Diseaster Science, Tohoku University, Sendai 8:東北大学加齢医学研究所スマート・エイジング国際共同研究センター / Smart Ageing International Research Center, Institute of Development, Aging and Cancer, Tohoku University, Sendai
Alleles of the apolipoprotein E 4 (ApoE4) have been regarded as a risk factor of Alzheimer's disease. Though volume reduction in medial temporal regions have been reported in adults carriers of ApoE4, the effects of ApoE4 on healthy children remain unclear. The aim of this study was to examine the influence of ApoE4 over childhood. We compared regional gray matter volumes of E4 carriers with those of E3 (wild type of APOE) carriers in 181 children and adolescents (63 males and 81 females) aged 8-21 using MRI. No differences in age and gender between E4 (N = 37) and E3 (N = 144) carriers. T1-weighted MR images were analyzed using the Statistical Parametric Mapping 8 (SPM8), and voxel-based morphometry (VBM) analysis was conducted using the diffeomorphic anatomical registration through exponentiated lie algebra (DARTEL) procedures with 8-mm smoothing. Age, gender and intracranial volume were used as covariates of no interest. We detected volume reduction in the left posterior hippocampus and the right parahippocampal gyurs (P <.001 uncorrected) in healthy children with E4 compared to E3 carriers. Those medial temporal reductions in E4 were significant with small volume correction (P <.05, FWE corrected for peak level). Our results suggest ApoE4 can induce reduction in medial temporal regions even in healthy children.