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演題詳細

Poster

学習・長期記憶
Learning and Long-term Memory

開催日 2014/9/12
時間 11:00 - 12:00
会場 Poster / Exhibition(Event Hall B)

ラットの嫌悪学習後の安静時における海馬と扁桃体の高周波の同期
The synchronized high frequency oscillation between the hippocampus and the amygdala during rest time after aversive stimuli in rats

  • P2-257
  • 久保田 隆文 / Takafumi Kubota:1 藤原 清悦 / Sei-etsu Fujiwara:1 船橋 利也 / Toshiya Funabashi:1 明間 立雄 / Tatsuo Akema:1 
  • 1:聖マリアンナ医科大学 / Department of Physiology, St. Mariannna University School of Medicine 

The synchronized high frequency oscillation between the hippocampus and the amygdala during rest time after aversive stimuli in rats.

Takafumi Kubota, Sei-etsu Fujiwara, Toshiya Funabashi, Tatsuo Akema

Department of Physiology, St. Marianna University School of Medicine


Memory consolidation process occurs during rest stage including slow-wave sleep by Sharp wave-ripple complex (SWRs) that observed in CA1 region of the Hippocampus (HPC). The SWRs interaction of the Basolateral amygdala (BLA) and the Hippocampus to different reward-expectations was reported, but the SWRs interaction of BLA and HPC to fear conditioning was unknown. To find out about this issue, we investigated the relationship of the freezing behavior reflecting fear memory and the synchronization of the high frequency oscillations from HPC and BLA during rest time. After recovery from the electrode implantation, rats were placed into the test box for foot shock. After the foot shock, rats were returned to their home cage, and local field potentials of HPC and BLA were recorded for 40-50 minutes. After 1 hour from foot shock, rats were placed into the test box again to record the freezing behavior by using the video camera. The synchronized high frequency oscillations (100-250 Hz) suggesting SWRs between HPC and BLA were observed during rest time at the home cage after foot shock. The rates of synchronous events between HPC and BLA were correlated with freezing behavior at 1 hour after the foot shock. This result suggests that interaction between high frequency oscillation of HPC and BLA affects the fear memory consolidation. In conclusion, this study provides new information that not only reword but also fear memory consolidation have relation to the SWRs.

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