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Parkinson's Disease and Related Disorders

開催日 2014/9/13
時間 14:00 - 15:00
会場 Poster / Exhibition(Event Hall B)

Invitation to collaborative curation effort to implement molecular mechanisms of Parkinson’s disease into a computationally tractable map

  • P3-300
  • 藤田 一広 / Kazuhiro A Fujita:1,2 Gebel Stephan / Stephan Gebel:3 Ostaszewski Marek / Marek Ostaszewski:3 Gawron Piotr / Piotr Gawron:3 Antony Paul / Paul Antony:3 Trefois Christophe / Christophe Trefois:3 Mosch Sabine / Sabine Mosch:3 松岡 由希子 / Yukiko Matsuoka:1 Ghosh Samik / Samik Ghosh:1,2 北野 宏明 / Hiroaki Kitano:1,2 Balling Rudi / Rudi Balling:3 
  • 1:システム・バイオロジー研究機構 / The Systems Biology Institute 2:理化学研究所 統合生命医科学研究センター / RIKEN Center for Integrative Medical Sciences, Yokohama, Japan 3:Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Esch-sur-Alzette, Luxembourg / Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Esch-sur-Alzette, Luxembourg 

Parkinson's disease (PD) is a major neurodegenerative movement disorder, and various biological processes have been implicated in its pathogenesis, such as mitochondrial dysfunction, alpha-synuclein aggregation, impaired degradation systems (autophagy and ubiquitin proteasome system), neuroinflammation and degeneration of dopaminergic neurons in substantia nigra. Knowledge on molecular mechanisms that are related to PD is rapidly accumulating but needs to be organized efficiently, so that mechanisms of PD can be analyzed computationally and explored visually to grasp signatures of experimental data. Therefore, we have compiled the knowledge from 716 peer-review articles (as of Apr. 2014) on PD-related biological processes into a computationally tractable and freely available map1,2.
We are continuously enriching information of the PD map to maintain and update molecular mechanisms in the PD map. Because of the complex nature of diverse PD-related biological processes and ever growing knowledge base, a major challenge is to do curate information comprehensively and precisely with a limited number of researchers. Therefore, to embody a collaborative curation approach of the PD map, we organized a first curation workshop of PD in Switzerland last December3, and will host a second one in Luxembourg this October4 and future ones. We would highly welcome your comments, feedback and contribution to this collaborative curation effort. In addition, you can also send direct feedback at any time via the PD map web site2, just by right clicking on the map.

1. K.A. Fujita, et al., Mol. Neurobiol. 49, 88-102 (2014).
2. Parkinson's disease map, http://pdmap.uni.lu/
3. As a satellite workshop of "The XX World Congress on Parkinson's Disease and Related Disorders", Geneva, Switzerland, Dec. 2013.
4. The 2nd International Parkinson's Disease Symposium, Luxembourg, Oct. 2014, https://neuroconference2014.uni.lu/

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