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演題詳細

Oral

突起伸展・回路形成 1
Axonal/Dendritic Growth and Circuit Formation 1

開催日 2014/9/13
時間 15:00 - 16:00
会場 Room J(313+314)
Chairperson(s) 古川 貴久 / Takahisa Furukawa (大阪大学蛋白質研究所 分子発生学研究室 / Laboratory for Molecular and Developmental Biology, Institute for Protein Research, Osaka University, Japan)
大森 義裕 / Yoshihiro Omori (大阪大学蛋白質研究所 / Institute for Protein Research, Osaka University, Japan)

神経活性依存的なフィードバックシグナルによる、ショウジョウバエ視神経細胞の前シナプスの活動部位における分子的再構成
Molecular remodeling of the presynaptic active zone of Drosophila photoreceptors via an activity-dependent feed-back signal

  • O3-J-3-1
  • 鈴木 崇之 / Takashi Suzuki:1 杉江 淳 / Atsushi Sugie:2 羽毛田 聡子 / Satoko Hakeda:1,4 鈴木 えみ子 / Emiko Suzuki:3 Tavosanis Gaia / Gaia Tavosanis:2 
  • 1:東工大・生命理工 / Grad Schl Biosci & Biotech, Tokyo Institute of Technology, Yokohama, Japan 2:DZNE、ボン、ドイツ / DZNE, Bonn, Germany 3:国立遺伝研構造遺伝学研究セ遺伝子回路 / National Inst Genetics, Mishima, Japan 4:日本学術振興会特別研究員 / JSPS Fellow, Japan 

Neural activity contributes to the regulation of the properties of synapses in sensory systems, allowing for adjustment to a changing environment. Little is known about how synaptic molecular components are regulated to achieve activity-dependent synaptic plasticity in central synapses. Here, we found that the presynaptic active zone in Drosophila photoreceptors undergoes structural and molecular remodeling, including Bruchpilot and DLiprin-α, upon mild but prolonged light exposure. The levels of neuronal activity of photoreceptors and of depolarization of their postsynaptic neurons are critical for the light-induced changes in photoreceptor active zone composition, suggesting the existence of a feedback signal. In search of the signal, we found that a reorganization of the microtubule meshwork acts downstream of the divergent canonical Wnt pathway, potentially via the kinesin-3 Immaculate connections. These data reveal changes in composition of active zones at central synapses upon natural stimuli and the molecular machinery that actively contributes to them.

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