演題詳細
Poster
痛覚、痒み、及びその障害
Pain, Itch and Their Disorders
開催日 | 2014/9/13 |
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時間 | 11:00 - 12:00 |
会場 | Poster / Exhibition(Event Hall B) |
神経障害性疼痛によって生じる負の情動と痛覚過敏への前部帯状回アストロサイトの関与
The contribution of astrocytes in the anterior cingulate cortex to the negative emotion and hyperalgesia under neuropathic pain
- P3-169
- 橋本 淳樹 / Junki Hashimoto:1 村瀬 一之 / Kazuyuki Murase:1,2 池田 弘 / Hiroshi Ikeda:1,2
- 1:福井大学院工学研究科知能システム工学専攻 / Dept. of Human and Artificial Intelligence Systems, Grad. Sch. of Engineering, Univ. of Fukui, Fukui, Japan 2:生命科学複合研究教育センター / Res. and Edu. Program Life Sci., Univ. of Fukui, Japan
The contribution of astrocytes in the anterior cingulate cortex to the negative emotion and hyperalgesia under neuropathic pain
Junki Hashimoto 1, Hiroshi Ikeda1,2 , Kazuyuki Murase1,2
1Dept. of Human and Artificial Intelligence Systems, Grad. Sch. of Engineering, Univ. of Fukui, Japan
2Res. and Edu. Program Life Sci., Univ. of Fukui, Japan
Recent studies suggest that the activation of astrocytes in the anterior cingulate cortex (ACC) contribute to negative emotion under inflammatory pain. However, whether the astrocytes in the ACC contribute to the negative emotion under neuropathic pain is still unknown. In this study, we demonstrated that spared nerve injury (SNI) in mice induced hyperalgesia and also induced depression and anxiety-like behaviors which are measured by forced swimming test and elevated-plus maze test, respectively. The immunohistochemical staining revealed that the significant increase of intensity in GFAP and S100B immunoreactivity, which are astrocytic marker, in the ipsilateral ACC at 7 days after SNI. Moreover, intra-ACC injection of L-alpha-aminoadipate (L-α-AA, 10nmol), an astroglial toxin, inhibited the decrease of immobilization time in the forced swimming test and the time spent in the open arms in the elevated-plus maze test in mice subjected to SNI. The decrease of pain threshold measured by hot-plate test in mice subjected to SNI was also inhibited by injection of L-α-AA in the ACC. These results suggest that the activated astrocytes in the ACC are involved in the negative emotion and the hyperalgesia under neuropathic pain.