For visual prostheses by means of intracortical microstimulation, it is necessary to develop devices that can generate spatio-temporal patterns of electrical stimuli to drive a large number of electrodes according to frame-sampled images. Here, we developed a prototype stimulation system consisting of a multi-channel current stimulator and wireless data/power transmitter and receiver controlled with microprocessors. The stimulator chip with the die size of 3.5×3.5 mm² was fabricated with 0.25-μm CMOS VLSI technology, to implement parallel eight current generators and multiplexers. The chip generates biphasic stimulus pulses through 64 electrodes in time-sharing mode at up to 200 frames/sec. The stimulus parameters can be set for each electrode by digital codes stored in built-in registers. On demand, the combination of anode and cathode electrodes for passing the stimulus current can be changed online. The maximal amplitude of the stimulus pulse is ˜±400 μA/phase at ±2.5 V supply. As for the wireless power transmission, a pair of 20-mm-diameter coils with a 5-mm gap was employed and the operational frequency is adjustable by programming on embedded microprocessors, in a range from 250 to 425 kHz with 1-kHz step. The available output power at ±2.5 V supply is up to 0.25 W. The wireless data communication was realized with discrete System-on-a-Chip components, by which the stimulus parameters as well as any data set via SPI bus format are transmitted/received between the transmitter and receiver. The signal quality of 2-Mbps data rate at 2.4-GHz band without packet/bit error was verified by using random 19-byte-length data with 0-dBm transmit power, with an inter-module distance of 1 cm or less. The receiver without the coil is 23×26×3 mm in width, length and height, respectively, and the total weight is 5 g including the coil.