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Paradigm shift in brain formation research

開催日 2014/9/13
時間 15:00 - 17:00
会場 Room D(503)
Chairperson(s) 河崎 洋志 / Hiroshi Kawasaki (金沢大学医薬保健研究域 脳・肝インターフェースメディシン研究センター分子神経科学部門 / Department of Biophysical Genetics, Graduate School of Medical Sciences, Kanazawa University, Japan)
松﨑 文雄 / Fumio Matsuzaki (理化学研究所 発生・再生科学総合研究センター / Laboratory for Cell Asymmetry, RIKEN Center for Developmental Biology, Japan)

Deciphering the rules of cell fate in the developing CNS

  • S3-D-1-2
  • Benjamin Simons:1 
  • 1:University of Cambridge, UK 

A fundamental question in development is how an ensemble of precursor cells is able to proliferate and differentiate to generate an organ of the correct size and cellular composition. In the central nervous system, proliferating neural precursors give rise to multiple types of neurons and glia, which establish intricate connections as they exit cell cycle and mature. This general scheme is recapitulated in different neuronal areas including the retina, spinal cord, and neocortex. To define the pattern of proliferation, differentiation, and cell fate choice, we have combined the results of static lineage tracing assays using transgenic models with continuous in vivo live-imaging to study the development and growth of fish retina. At the same time, we have used a transgenic model based on the MADM (Mosaic Analysis with Double Markers) system to study the proliferative and differentiation potential of neural precursors in the development of mouse neocortex. In both cases, we make use of statistical and computational approaches to develop a quantitative biophysical modeling scheme to define the rules of cell fate choice. We compare and contrast developmental strategies in these two neuroepithelial tissues, the potential role of stochasticity in the specification of fate choice, and the implications of these findings on the mechanisms of molecular regulation.

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