演題詳細
Oral
創薬・神経保護
Drug Development and Neuroprotection
| 開催日 | 2014/9/11 |
|---|---|
| 時間 | 9:00 - 10:00 |
| 会場 | Room J（313+314） |
| Chairperson(s) | 池田 華子 / Hanako Ohashi-Ikeda (京都大学医学部附属病院 臨床研究総合センター / Institute for Advancement of Clinical and Translational Science, Kyoto University Hospital, Japan) 東田 千尋 / Chihiro Tohda (富山大学和漢医薬学総合研究所神経機能学分野 / Division of Neuromedical Science, Institute of Natural Medicine, University of Toyama, Japan) |
Connecting dots from identification, expression and interaction of estrogen receptor β interacting proteins in the brain: provide hint for drug targeting
- O1-J-1-2
- Vijay Paramanik:1 Mahendra K Thakur:2
- 1:Indira Gandhi National Tribal University, Amarkantak (MP), India 2:Banaras Hindu University, Varanasi, India
Connecting dots from identification, expression and interaction of estrogen receptor β interacting proteins in the brain: provide hint for drug targeting
Paramanik, V* 1, 2., and Thakur M.K1.
1Biochemistry and Molecular Biology Laboratory, Department of Zoology, Banaras Hindu University, Varanasi -221 005, India
2Department of Zoology, Indira Gandhi National Tribal University, Amarkantak-484 886, India
Corresponding authors Email٭: vijayparamanik@gmail.com Tel: 91 -0729- 269790
Following binding of estrogen, estrogen receptor (ER) β recruits a host of proteins called coregulators. These make a bridge between basal transcription machinery RNA pol II and transcription factors with ERs. In fact, coregulators are responsible for differential ER dependent functions in the brain. We identified ERβ interacting proteins in the nuclear and mitochondrial extract prepared from male adult (26 week) brain and studied their age and sex dependent variation. Interestingly, we found ERβ interacting proteins in mitochondrial extract have consensus motifs similar to nuclear proteins. This has raised many important issues, more strikingly, regarding the motif specificity, as most of the coregulators reported earlier were from other tissues and related to diseases. In conclusion, tissue and receptor specificity of coregulators and their motifs might be useful in designing peptide specific agonist and/or antagonist which can regulate specific estrogen action and be used in therapeutics.
Keywords: Coregulators; Estrogen receptor; Estrogen action; Specificity; Brain; Peptide agonist/antagonist