演題詳細
Symposium
小規模モデル動物による脳機能の基本原理へのアプローチ
Elucidation of principle of neural circuits using small circuits
| 開催日 | 2014/9/12 |
|---|---|
| 時間 | 17:10 - 19:10 |
| 会場 | Room F（302） |
| Chairperson(s) | 上川内 あづさ / Azusa Kamikouchi (名古屋大学大学院理学研究科 生命理学専攻 / Graduate School of Sciene, Nagoya University, Japan) 森 郁恵 / Ikue Mori (名古屋大学大学院理学研究科 / Graduate School of Sciene, Nagoya University, Japan) |
To turn left or right? A circuit motif for a two alternative behavioral choice in the zebrafish hindbrain
- S2-F-3-5
- Minoru Koyama:1,2 Francesca Minale:3 Jennifer Shum:3 Nozomi Nishimura:3 Chris B Scahffer:3 Joseph Fetcho:2
- 1:HHMI/Janelia Farm, Ashuburn, VA, USA 2:Department of Neurobiology and Behavior, Cornell University, Ithaca, NY, USA 3:Department of Biomedical Engineering, Cornell University, Ithaca, NY, USA
Animals collect sensory information from the world and use their brains to make adaptive choices about how to respond to it. Defining the neuronal networks for these behavioral choices at the cellular level from sensory input to motor output has proven difficult. Here we reveal a network for one of the most fundamental behavioral choices made by bilaterally symmetric animals: whether to respond to a visual, auditory, tactile or other sensory stimulus by moving to the left or to the right. We define the network connectivity for the lateralized escape behavior of zebrafish and then test the role of the key neurons by using laser ablation and behavioral studies. The structure of the network matches theoretically optimal networks for weighing sensory evidence to drive decision making. Repetitions of this network motif in a recently discovered hindbrain ground plan may lie at the foundation of other lateralized behavioral choices made by brains.