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Rhythmic Motor Pattern Generation

開催日 2014/9/11
時間 16:00 - 17:00
会場 Poster / Exhibition(Event Hall B)

PSD-95 protein expression in rat oro-maxillofacial motoneurons during postnatal development

  • P1-132
  • 田中 輝 / Akira Tanaka:1 石濱 孝二 / kohji ishihama:1,3 脇坂 聡 / satoshi wakisaka:2 本間 志保 / shiho honma:2 古郷 幹彦 / mikihiko kogo:1 
  • 1:大阪大学大学院歯学研究科 口腔外科学第一教室 / First Department of Oral and Maxillofacial Surgery,Graduate School of Dentistry Osaka University, Osaka, Japan 2:大阪大学大学院歯学研究科 口腔解剖学第一教室 / Department of Oral Anatomy and Developmental Biology,Graduate School of Dentistry Osaka University, Osaka, Japan 3:大阪警察病院 歯科口腔外科 / Department of Dentistry, Oral and Maxillofacial Surgery, Osaka Police Hospital , Osaka, Japan 

Chemical synapses contain a number of diverse proteins, which form the postsynaptic density (PSD), and these are involved in synaptic structure, neurotransmission and signal transduction. PSD-95 is implicated in the formation and maturation of excitatory synapses. PSD-95 regulates the localization of NMDA receptors by means of binding with NMDA receptor subunit 2 (NR2). Rhythmical oro-maxillofacial activities, such as suckling and chewing, are generated in the brainstem, and we showed that NMDA
receptors play a critical role in the rhythm and pattern generation and signal transmission around the trigeminal motor nucleus during prenatal and early postnatal development. Here, we immunohistochemically examined the temporal distribution of PSD-95 protein in developing rat brainstem from suckling to the mature chewing stage. There was early emergence of PSD-95 expression in the interneurons located in the medial region of the trigeminal motor nucleus. This observation supports the notion that the central pattern generator for rhythmical jaw movements is located peritrigeminal area.

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