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Olfactory and Auditory system

開催日 2014/9/13
時間 9:00 - 10:00
会場 Room J(313+314)
Chairperson(s) 山口 正洋 / Masahiro Yamaguchi (東京大学大学院医学系研究科 細胞分子生理学教室 / Department of Physiology, Graduate School of Medicine, the University of Tokyo, Japan)
風間 北斗 / Hokuto Kazama (独立行政法人 理化学研究所 脳科学総合研究センター 知覚神経回路機構研究チーム / Laboratory for Circuit Mechanisms of Sensory Perception Brain Science Institute, RIKEN, Japan)

Direct roles of the main olfactory system in mouse social behaviour

  • O3-J-1-4
  • 松尾 朋彦 / Tomohiko Matsuo:1 服部 達哉 / Tatsuya Hattori:2 浅場 明莉 / Akari Asaba:2 井上 直和 / Naokazu Inoue:3,4 菊水 健史 / Takefumi Kikusui:2 小早川 令子 / Reiko Kobayakawa:1 小早川 高 / Ko Kobayakawa:1,5 
  • 1:大阪バイオサイエンス研 / Department Functional Neuroscience, Osaka Bioscience Institute, Osaka, Japan 2:麻布大学大学院・獣医・動物・伴侶動物学研究室 / Companion Animal Research, Sch of Veterinary Medicine, Azabu Univ, Sagamihara, Japan 3:大阪大微生物病研 / Research Institute for Microbial Diseases, Osaka University, Osaka, Japan 4:福島県立医科大・医学部附属生体情報伝達研 / Department of Cell Science, Institutes for Biomedical Sciences, School of Medicine, Fukushima Medical University, Fukushima, Japan 5:JSTさきがけ / PRESTO, Japan Science and Technology Agency, Saitama, Japan 

Pheromones induce social behaviours through the main olfactory system (MOS) and vomeronasal system (VNS). However, functional dissociation of the MOS and VNS in pheromone processing has never been achieved, because a complete loss of the MOS blocks access of pheromones to the VNS. Therefore, assessing the direct contribution of the MOS to social behaviour is a challenge.

Here, we show that mice with loss of function only in the dorsal zone of the MOS maintain pheromone recognition and VNS activity, but fail to demonstrate attraction to female urine and accompanying ultrasonic vocalisations, chemoinvestigatory preference, aggression, or maternal behaviours. Functional dissociation of pheromone detection and induction of behaviours enabled us to identify the anterior olfactory nucleus (AON) as a regulator of social behaviours downstream from the MOS and the MOS-AON pathway as a conveyor of pheromone information to multiple amygdaloid and hypothalamic nuclei, independent of the VNS. Identification of the MOS-AON pathway may shed light on pheromone signalling in animals that do not possess a functional VNS, such as humans.

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