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演題詳細

Poster

シナプス
Synapse

開催日 2014/9/12
時間 14:00 - 15:00
会場 Poster / Exhibition(Event Hall B)

ヒストン脱アセチル化酵素は可溶性Aβオリゴマーにより誘導されるドレブリンクラスター減少に関与する
Histone deacetylase is involved in the decrease of drebrin cluster density induced by amyloid beta oligomers

  • P2-034
  • 石塚 佑太 / Yuta Ishizuka:1 清水 英雄 / Hideo Shimizu:1 白尾 智明 / Tomoaki Shirao:1 
  • 1:群馬大院医神経薬理 / Dept Neurobiol and Behav, Gunma Univ Grad Sch Med, Gunma, Japan 

Dendritic spine defects are found in a number of cognitive disorders, including Alzheimer's disease (AD). Amyloid beta (Aβ) toxicity is mediated not only by the fibrillar form of the protein, but also by the soluble oligomers (Aβ-derived diffusible ligands, ADDLs). Recent studies show that histone deacetylase (HDAC) activity is elevated in the AD mouse model, and that memory impairments in these animals can be ameliorated by HDAC inhibitors. In addition, spine loss and memory impairment in HDAC2 over-expressing mice are ameliorated by chronic HDAC inhibitor treatment. Therefore, we hypothesized that the regulation of histone acetylation/deacetylation is critical to synaptic functioning. In this study, we examined the relationship between HDAC activity and synaptic defects induced by ADDLs using an HDAC inhibitor, suberoylanilide hydroxamic acid (SAHA). We show that ADDLs reduce the cluster density of drebrin along dendrites. SAHA markedly increased the acetylation of histone proteins, and it simultaneously attenuated the ADDL-induced decrease in drebrin cluster density. In comparison, SAHA treatment did not affect the density of drebrin clusters in control neurons. These findings suggest that HDAC is involved in ADDL-induced synaptic defects, and that the regulation of histone acetylation plays an important role in modulating actin cytoskeletal dynamics in dendritic spines under cellular stress conditions, such as ADDL exposure.

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