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演題詳細

Poster

神経保護、神経毒性と神経炎症
Neuroprotection, Neurotoxicity and Neuroinflammation

開催日 2014/9/11
時間 11:00 - 12:00
会場 Poster / Exhibition(Event Hall B)

閉鎖性脳傷害における脳組織再生とネスチン陽性活性化アストロサイトにおけるSTAT3シグナル
STAT3 signaling in perilesional nestin-expressing reactive astrocyte is required for cortical recovery after closed-head injury

  • P1-333
  • 渡辺 愛理 / Airi Watanabe:1 森田 光洋 / Mitsuhiro Morita:1 
  • 1:神戸大学・理・生物 / Kobe Univ Dept Biol 

Our novel closed head injury model designated "Photo injury", which is created by exposing intense light to cortical tissue through thinned-skull cranial window, shows substantial cortical recovery (Suzuki et al, 2012). The recovering region is characterized by the prominent accumulation of perilisional nestin-expressing reactive astrocyte. In order to address the roles of the perilesional reactive astrocyte in wound healing, STAT3, which is crucial for astrocyte activation, has been ablated in nestin-expressing cells by using Nestin-Cre/STAT3flox/flox mouse. Mice after more than seven days post-injury showed significantly less accumulation of perilesional reactive astrocytes, and larger lesion size in the STAT3-ablated group than in wild type group. The importance of STAT3 signaling was further confirmed by ablating SOCS3, which suppress cytokine mediated STAT3 activation, in the nestin-expressing reactive astrocyte by using Nestin-Cre/SOCS3flox/flox mouse. The SOCS3-ablated groups showed significantly smaller lesion size after more than seven days post-injury, as well as significantly larger region covered by perilesional reactive astrocyte, than corresponding wild type group. Our results indicates that cytokine-mediated STAT3 activation in perilesionl astrocytes leads to the accumulation of nestin-expressing reactive astrocyte, and then promote wound healing following closed-head injury.

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