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Cell Migration and Layer/Nuclear Formation

開催日 2014/9/12
時間 14:00 - 15:00
会場 Poster / Exhibition(Event Hall B)

Generation of sexually dimorphic limbic system neuronal populations from Dbx1+ embryonic progenitor pools

  • P2-086
  • 江角 重行 / Shigeyuki Esumi:1 ヤスミン カマール / Kamal Yasmin:2 平田 務 / Tsutomu Hirata:3 ケィティ ソコロウスキィ / Sokolowski Katie:2 リー ペイジュン / Peijun Li:2 ニラオ シャア / Shah Nirao:6 アレクサンドラ ピエラーニ / Pierani Alessandra:4 モーリー ハンスマン / Huntsman Molly:5 玉巻 伸章 / Nobuaki Tamamaki:1 ジョシュア コルビン / Corbin Joshua:2 
  • 1:熊本大学大学院生命科学研究部・脳回路構造学分野 / Grad. School of Med. Sci., Kumamoto-Univ, Kumamoto City, Japan, Japan,  2:小児医療センター,Washington DC, USA / Children's National Medical Center, Washington DC, USA  3:愛媛大学上級研究員センター, 東温市, 愛媛県 / Senior Research Fellow Center, Ehime University, Toon, Ehime, Japan  4:パリ・ディドゥロ大学ジャック・モノー研, パリ, フランス / Jacques Monod, Universite Paris Diderot, Paris, France 5:コロラド大学, Aurora,CO, USA / University of Colorado School of Medicine, Aurora, CO, USA 6:UCSF, CA, USA / Department of Anatomy, University of California-San Francisco, CA 

Innate behaviors in mammals are mediated by a connected circuit of limbic system structures, which most prominently includes the olfactory system, bed nucleus of stria terminalis (BNST), medial amygdala (MeA) and hypothalamus. Our previous work (Hirata et al., Nature Neuroscience, 2009; Carney et al., Neural Development, 2010) revealed that Dbx1+ progenitors derived from a specialized progenitor niche generate an electrophysiologically homogeneous subpopulation of MeA inhibitory projection neurons that are distinct from their non-Dbx1 derived populations. Here, we reveal that in the MeA, Dbx1 -derived neurons possess a unique molecular profile of expression of behaviorally relevant genes and in a sexually dimorphic manner. Consistent with this, Dbx1 and non-Dbx1 MeA projection neurons appear to have biases in the processing of specific aspects of innate information. Thus, it appears that subpopulations of MeA neurons that can be divided according to expression of developmentally regulated and/or functionally relevant genes are dedicated to processing different aspects of innate information.

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