演題詳細
Oral
言語機能
Language
| 開催日 | 2014/9/12 |
|---|---|
| 時間 | 10:00 - 11:00 |
| 会場 | Room H（304） |
| Chairperson(s) | 酒井 邦嘉 / Kuniyoshi L. Sakai (東京大学大学院総合文化研究科 / Dapartment of Basic Science, Graduate School of Arts and Sciences, The University of Tokyo, Japan) 松本 理器 / Riki Matsumoto (京都大学大学院医学研究科 てんかん・運動異常生理学講座 / Department of Epilepsy, Movement Disorders and Physiology, Kyoto University, Japan) |
統辞関連ネットワークが示す神経膠腫による異常な機能的結合パターン
Abnormal functional connectivity patterns in syntax-related networks caused by a glioma
- O2-H-2-2
- 金野 竜太 / Ryuta Kinno:1,2 村垣 善浩 / Yoshihiro Muragaki:3 丸山 隆志 / Takashi Maruyama:3 太田 真理 / Shinri Ohta:2 酒井 L. 邦嘉 / Kuniyoshi L. Sakai:2
- 1:昭和大学横浜市北部病院 / Dept of Intern Med, Showa Univ Northern Yokohama Hosp, Kanagawa, Japan 2:東京大院総合文化研 / Dept of Basic Sci, Univ of Tokyo, Tokyo, Japan 3:東京女子医大脳神経外科 / Dept of Neurosurg, Tokyo Women's Med Univ, Tokyo, Japan
We have previously demonstrated that the patients with a glioma in the left lateral premotor cortex (LPMC group) and the opercular/triangular parts (F3op/F3t) of the left inferior frontal gyrus (F3 group) showed agrammatic comprehension, while patients with a glioma in the other left frontal regions (Other group) showed normal performances (Brain 137, 1193-1212). We have further shown the existence of three syntax-related networks. The first network (network I) consists of the left F3op/F3t, left intraparietal sulcus, right frontal regions, pre-supplementary motor area, and right temporal regions. The second network (network II) consists of the left LPMC, left angular gyrus, lingual gyrus, and cerebellar nuclei. The third network (network III) consists of the left ventral frontal and posterior temporal regions. In the present study, we examined whether or not the functional connectivity patterns in these syntax-related networks were preserved even when there was a left frontal glioma. The functional connectivities within and between networks were assessed by a partial correlation method for the time-series data. For the normal controls, the non-diagonal correlations within networks were significantly greater than those between any of two networks (a permutation test, p < 0.0001). In the patients' brain, such network-boundary effects were observed in the Other group (p < 0.006), but not in the F3 and LPMC groups (p > 0.3). Moreover, we found that the mean r values of the crosstalks between any of the two networks were higher for each of the three patient groups than the normal group (p < 0.0001). For the Other group, the mean r value of the crosstalk between networks I and III was significantly higher than that between networks I and II or between networks II and III (p < 0.01). These results indicate that the functional connectivity patterns in syntax-related networks became abnormal due to the presence of a glioma. We thus conclude that abnormality in such functional connectivity should be carefully examined for aphasic patients, even if they show apparently normal performances.