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Spinal cord Motor Neurous and Muscle

開催日 2014/9/11
時間 16:00 - 17:00
会場 Poster / Exhibition(Event Hall B)

The number of gamma motoneurons decreased in Otsuka Long-Evans Tokushima Fatty (OLETF) rat

  • P1-124
  • 村松 憲 / Ken Muramatsu:1 玉木 徹 / Toru Tamaki:1 駒形 純也 / Junya Komagata:1 丹羽 正利 / Masatoshi Niwa:2 石黒 友康 / Tomoyasu Ishiguro:1 長谷川 達也 / Tatsuya Hasegawa:3 佐々木 誠一 / Sei-ichi Sasaki:4 
  • 1:健康科学大学 / Dept Physical Therapy, Health Science University, Yamanashi, Japan 2:杏林大学 作業療法学科 / Dept. Occupational Therapy, Kyorin Univ, Tokyo, Japan 3:山梨県富士山科学研究所 環境共生研究部 / Div. Human Environmental Science, Mount Fuji Research Institute, Yamanashi, Japan 4:茨城県立医療大学 医科学センター / Center for Medical Sciences, Ibaraki Prefectural Univ of Health Sciences, Ibaraki, Japan 

We previously reported that diabetic polyneuropathy predominantly targets gamma motoneurons of the distal muscle in type I diabetic rats. Alterations in the number and size of motoneurons, however, weren't studied in type II diabetic rats. In this study, we examined the number and cross-sectional area in the medial gastrocnemius (MG) motoneurons of 45-week-old male Otsuka Long-Evans Tokushima Fatty (OLETF) rat and their control strain Long-Evans Tokushima Otsuka (LETO) rat. OLETF rat is an animal model of type 2 diabetes and almost 100‰ of male OLETF rats develop diabetes at 25 weeks of age.
MG motoneurons of OLETF/LETO rats were retrogradely labeled by dextran Texas-Red, and the number and cross-sectional area of cell bodies were examined. Significantly fewer labeled MG motoneurons were found in the OLETF rats as compared with LETO rat. The distribution of mean cross-sectional area of cell bodies of MG motoneurons of both animals was bimodal with optimal threshold between the two cell populations at 600 μm2. The number of smaller MG motoneurons (<600 μm2) was reduced in OLETF rats. As opposed to smaller cells, the number of larger cells wasn't decreased in OLETF rats. Previous studies indicate larger cell bodies were presumed to be alpha-motoneurons and those with smaller cell bodies were presumed to be gamma. We conclude that it is highly possible that diabetic polyneuropathy in type 2 diabetic animals predominantly targets gamma motoneurons.

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