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Social Behavior

開催日 2014/9/12
時間 14:00 - 15:00
会場 Poster / Exhibition(Event Hall B)

Glutamatergic input in the dorsal raphe nucleus as the determinant of the level of aggression in male mice

  • P2-276
  • 高橋 阿貴 / Aki Takahashi:1 小出 剛 / Tsuyoshi Koide:1 
  • 1:国立遺伝研系統生物研究セマウス開発 / Mouse Genomics Resource Lab, National Institute of Genetics, Mishima, Japan 

The serotonin (5-HT) system has been studied more than any other neurotransmitter for its role in the neurobiology of aggression. However, it is not clear which mechanisms modulate the 5-HT system to promote escalated aggression, and also how 5-HT system is behaving during aggressive behavior. The 5-HT neurons in the mammalian forebrain originate mainly from the dorsal raphe nucleus (DRN). Previously, we showed that local administration of GABAB receptor agonist baclofen into the DRN increased 5-HT release in the medial prefrontal cortex (mPFC), and also escalated aggressive behavior in male mice. We then found that baclofen increased glutamate release, but not GABA release, within the DRN, and the direct injection of L-glutamate into the DRN caused an escalation of aggression in the male mice. Thus, glutamatergic input in the DRN seems to have an important role on the aggressive behavior. In this study, we measured the glutamatergic input in the DRN during aggressive behavior by using in vivo microdialysis. We found that there was an increase of extracellular glutamate in the DRN during an aggressive encounter. Also, when animal shows escalated level of aggressive behavior after social provocation, there was a further increase of glutamate input in the DRN. Thus, glutamatergic input in the DRN may be one of the determinant of the level of aggression. We are currently measuring the change of 5-HT release in the DRN and in the mPFC during aggressive behavior and also during instigation-heightened aggression to examine how the enhancement of glutamate input in the DRN changes the activation of 5-HT neurons.

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